Results 11 to 20 of about 5,522,894 (323)

Single Cell Isolation and Analysis [PDF]

Frontiers in Cell and Developmental Biology, 2016
Increasing evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their peculiar function and fate.
Ping Hu, wenhua Zhang, Hongbo Xin, Glenn Deng   +3 more
doaj   +4 more sources

Electrochemical Nanoprobes for Single-Cell Analysis [PDF]

ACS Nano, 2014
The measurement of key molecules in individual cells with minimal disruption to the biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal analytical tools because of their small size and their potential for high spatial and temporal resolution recordings.
Actis, Paolo, Sergiy, Tokar, Jan, Clausmeyer, Babak, Babakinejad, Sofya, Mikhaleva, Cornut, Renaud, Yasufumi, Takahashi, Ainara, Lopez-Cordoba, Pavel, Novak, Andrew I., Shevchuck, Jennifer A., Dougan, Sergei G., Kazarian, Petr V., Gorelkin, Alexander S., Erofeev, Igor V., Yaminsky, Patrick R., Unwin, Wolfgang, Schuhmann, David, Klenerman, Dmitri A., Rusakov, Elena V., Sviderskaya, E., Korchev Yuri   +20 more
openaire   +7 more sources

Single Cell Analysis in Vascular Biology [PDF]

Frontiers in Cardiovascular Medicine, 2020
The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within tissues.
Nicholas W. Chavkin, Karen K. Hirschi, Karen K. Hirschi   +2 more
doaj   +4 more sources

Chemical Analysis of Single Cells [PDF]

Analytical Chemistry, 2011
In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore, it is important to analyze them on an individual basis in order to elucidate the role each cell plays in the function of these systems ...
Yuqing Lin, Raphaël Trouillon, Andrew G. Ewing, Andrew G. Ewing, Gulnara Safina   +4 more
  +9 more sources

Single Cell Analysis

Analytical Sciences, 2017
The growing interest of analytical chemists in the research and practical applications of single-cell analysis (SCA) is demonstrated by permanently increasing number of scientific papers, reviews, and specialized conferences in the past decade. Nowadays, the field of SCA becomes divided into areas of single-cell genomics, transcriptomics, proteomics ...
Andrea Cossarizza, J. Paul Robinson
  +9 more sources

Transcriptome Analysis of Single Cells [PDF]

Journal of Visualized Experiments, 2011
Many gene expression analysis techniques rely on material isolated from heterogeneous populations of cells from tissue homogenates or cells in culture. In the case of the brain, regions such as the hippocampus contain a complex arrangement of different cell types, each with distinct mRNA profiles.
Jacqueline Morris, Jennifer M. Singh, James Eberwine   +2 more
openaire   +3 more sources

Trajectory-based differential expression analysis for single-cell sequencing data [PDF]

, 2020
Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital to discover genes that are (i) associated with the lineages in the ...
Cannoodt, Robrecht, Clement, Lieven, Dudoit, Sandrine, Roux de Bézieux, Hector, Saelens, Wouter, Saeys, Yvan, Street, Kelly, Van den Berge, Koen   +7 more
core   +2 more sources

Single-cell western blotting. [PDF]

, 2014
To measure cell-to-cell variation in protein-mediated functions, we developed an approach to conduct ∼10(3) concurrent single-cell western blots (scWesterns) in ∼4 h.
Herr, Amy E, Hughes, Alex J, Kang, Chi-Chih, Schaffer, David V, Spelke, Dawn P, Xu, Zhuchen   +5 more
core   +2 more sources

Microfluidics-Based Single-Cell Research for Intercellular Interaction

Frontiers in Cell and Developmental Biology, 2021
Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and medical studies, such as stem cell differentiation, immunotherapy and tissue engineering. Traditional methods employed for delving into intercellular interaction
Long Pang, Long Pang, Jing Ding, Xi-Xian Liu, Zhixuan Kou, Zhixuan Kou, Lulu Guo, Lulu Guo, Xi Xu, Xi Xu, Shih-Kang Fan   +10 more
doaj   +1 more source

An end-to-end software solution for the analysis of high-throughput single-cell migration data [PDF]

, 2017
The systematic study of single-cell migration requires the availability of software for assisting data inspection, quality control and analysis. This is especially important for high-throughput experiments, where multiple biological conditions are tested
Ampe, Christophe, Huyck, Lynn, Martens, Lennart, Masuzzo, Paola, Simiczyjew, Aleksandra, Van Troys, Marleen   +5 more
core   +2 more sources