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Studying Cancer Heterogeneity by Single-Cell RNA Sequencing
2019A major hurdle for the treatment of cancer is the incomplete understanding of its evolution through the course of its emergence, dispersal, and relapse. Genetic and epigenetic changes in combination with external cues and selective forces are the driving factors behind tumor heterogeneity.
Johannes W, Bagnoli +3 more
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Single-Cell RNA-Sequencing of RVFV Infection
On the RNA level, viral infections are characterized by perturbations in the host cell transcriptome as well as the development of viral genetic information. Investigating the abundance and dynamic of RNA molecules can provide ample information to understand many aspects of the infection, from viral replication to pathogenesis.openaire +2 more sources
Single-Cell Sequencing of 3′ RNA Transcripts
Single-cell RNA sequencing (scRNA-seq) enables the measurement of RNA expressed from individual cells within a tissue or population. RNA expression profiles may be used to draw conclusions about cellular states, cell subtypes within the population, responses to perturbations, and cellular behavior in the context of disease.openaire +2 more sources
Treatment of muscle‐invasive and advanced bladder cancer in 2020
Ca-A Cancer Journal for Clinicians, 2020Vaibhav G Patel +2 more
exaly
Mitochondrial sequencing and single-cell RNA sequencing combination
As demand for new and effective treatments for cancer increases, insight into cell dynamics in cancers is necessary. In 2018, a new technique called single-cell RNA sequencing (scRNA-seq) was developed, opening a new door to understanding individual cell fates and gene expressions in complex organisms. However, the technique alone still has limitationsAnh L. Nguyen, Katherine Nathanson
openaire +1 more source
Single-cell RNA sequencing at isoform resolution
Nature Biotechnology, 2020openaire +2 more sources
Treatment of renal cell carcinoma: Current status and future directions
Ca-A Cancer Journal for Clinicians, 2017Pedro Coelho Barata, Brian I Rini
exaly
The role of the microbiome in cancer development and therapy
Ca-A Cancer Journal for Clinicians, 2017Aadra P Bhatt, Matthew R Redinbo
exaly
Translating cancer genomes and transcriptomes for precision oncology
Ca-A Cancer Journal for Clinicians, 2016Sameek Roychowdhury, Arul M Chinnaiyan
exaly
Shifting concepts in rectal cancer management
Ca-A Cancer Journal for Clinicians, 2012Rodrigo Perez
exaly