Results 41 to 50 of about 865,522 (266)

NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are ...
A. V. Shatalova, A. S. Yakubova, V. V. Palimpsestov, I. B. Esmagambetov   +3 more
doaj   +1 more source

Plant-derived single domain COVID-19 antibodies

Journal of Controlled Release, 2023
Data show a decrease in the risk of hospitalization and death from COVID-19. To date, global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are urgently needed to prevent and cure infection among naïve and even vaccinated people.
Shen, Andrew M., Malekshah, Obeid M., Pogrebnyak, Natalia, Minko, Tamara   +3 more
openaire   +2 more sources

sdAb-DB: The Single Domain Antibody Database [PDF]

ACS Synthetic Biology, 2018
The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range of applications, including as a rational design tool, and are ...
Emily E. Wilton, Michael P. Opyr, Senthilkumar Kailasam, Ronja F. Kothe, Hans-Joachim Wieden   +4 more
openaire   +2 more sources

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

Toxins, 2011
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson   +10 more
doaj   +1 more source

Single domain antibodies as a powerful tool for high quality surface plasmon resonance studies.

PLoS ONE, 2015
Single domain antibodies are recombinantly expressed functional antibodies devoid of light chains. These binding elements are derived from heavy chain antibodies found in camelids and offer several distinctive properties for applications in biotechnology
Eduardo Antonio Della Pia, Karen L Martinez   +1 more
doaj   +1 more source

Progress of Single-domain Antibodies in Molecular Imaging of Tumors

Zhongliu Fangzhi Yanjiu, 2019
A single-domain antibody (sdAb) is the variable region extracted from antibodies with only heavy chains found in camelid serum. Single-domain antibodies have the characteristics of easy expression, good solubility, great stability and weak immunogenicity.
ZHANG Meixin, LIU Teli, GUO Xiaoyi, XU Xiaoxia, ZHU Hua, YANG Zhi   +5 more
doaj   +1 more source

Single‐Domain Antibodies and Their Utility

Current Protocols in Immunology, 2013
AbstractEngineered monoclonal antibody fragments have gained market attention due to their versatility and tailor‐made potential and are now considered to be an important part of future immunobiotherapeutics. Single‐domain antibodies (sdAbs), also known as nanobodies, are derived from VHHs [variable domains (V) of heavy‐chain‐only antibodies (HCAb)] of
Baral, Toya Nath, MacKenzie, Roger, Ghahroudi, Mehdi Arbabi   +2 more
openaire   +4 more sources

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies

Scientific Reports, 2021
The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi, Daisuke Kuroda, Makoto Nakakido, Akikazu Murakami, Kouhei Tsumoto   +4 more
doaj   +1 more source

Preclinical Targeted α- and β−-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies

Cancers, 2020
HER2-targeted therapies have drastically improved the outcome for breast cancer patients. However, when metastasis to the brain is involved, current strategies fail to hold up to the same promise.
J. Puttemans, Yana Dekempeneer, J. Eersels, Heleen Hanssens, P. Debie, M. Keyaerts, A. Windhorst, F. van der Aa, Q. Lecocq, K. Breckpot, A. Morgenstern, F. Bruchertseifer, T. Lahoutte, N. Devoogdt, M. D'Huyvetter   +14 more
semanticscholar   +1 more source

Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody.

PLoS ONE, 2014
Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation.
Dan Zabetakis, Mark A Olson, George P Anderson, Patricia M Legler, Ellen R Goldman   +4 more
doaj   +1 more source