Results 41 to 50 of about 1,193,038 (282)

Simulated single molecule microscopy with SMeagol

, 2016
SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule microscopy data ...
Boucharin, Alexis, Elf, Johan, Fange, David, Lindén, Martin, Ćurić, Vladimir   +4 more
core   +2 more sources

Surface Modification of Fluorescent Nanodiamonds for Biological Applications

Nanomaterials, 2021
Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility.
Hak-Sung Jung, Keir C. Neuman
doaj   +1 more source

Single-molecule pulling: phenomenology and interpretation

, 2013
Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that
Allinger, Ashkin, Basu, Berendsen, Bustamante, Camden, Chodera, Crooks, Evans, Ferrenberg, Franco, Franco, Franco, Frenkel, Freund, Gebhardt, Gunari, Halperin, Harris, Harvey, Hess, Heymann, Hoover, Hub, Huguet, Hummer, Hummer, Hummer, Imparato, Isralewitz, Izrailev, Jarzynski, Jarzynski, Jarzynski, Jarzynski, Kim, Kirkwood, Kirmizialtin, Kreuzer, Kubo, Kumar, Lee, Liphardt, Liphardt, Marsili, Martyna, McCullagh, Minh, Moerner, Neuman, Newman, Nitzan, Nosé, Oberhauser, Park, Phillips, Pohorille, Rief, Ritort, Roux, Rubinstein, Schäfer, Strick, Süzen, Thijssen, Weiss   +65 more
core   +1 more source

Variations in Cell Surfaces of Estrogen Treated Breast Cancer Cells Detected by A Combined Instrument for Far-Field and Near-Field Microscopy

Analytical Cellular Pathology, 2002
The response of single breast cancer cells (cell line T‐47D) to 17β‐estradiol (E2) under different concentrations was studied by using an instrument that allows to combine far‐field light microscopy with high resolution scanning near‐field (AFM/SNOM ...
P. Perner, A. Rapp, C. Dressler, L. Wollweber, J. Beuthan, K. O. Greulich, M. Hausmann   +6 more
doaj   +1 more source

Automatic classification and segmentation of single-molecule fluorescence time traces with deep learning

Nature Communications, 2020
Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications of ...
Jieming Li, Leyou Zhang, Alexander Johnson-Buck, Nils G. Walter   +3 more
doaj   +1 more source

Dynamical conductance measurement of single molecular junctions with both high-speed and high-precision

AIP Advances, 2022
Real-time and rapid monitoring of the electron transport in nanoscale structures is critical for understanding many fundamental phenomena. However, it is not possible to rapidly record the dynamical current that varied across several orders of magnitude ...
Haiyang Liu, Zhikai Zhao, Xueyan Zhao, Maoning Wang, Tianran Zhao, Dong Xiang   +5 more
doaj   +1 more source

Confined environment facilitates stacked conformations in Holliday Junction

Chemical Physics Impact, 2023
Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. It is a highly dynamic structure and transitions between two stacked isomers through an intermediate open conformer. However, the insight
Priya Agarwal, Sahil Hasan Kabir, Nibedita Pal   +2 more
doaj   +1 more source

Modeling transport through single-molecule junctions

, 2005
Non-equilibrium Green's functions (NEGF) formalism combined with extended Huckel (EHT) and charging model are used to study electrical conduction through single-molecule junctions.
A. H. Flood, A. Nitzan, A. Onipko, A. Ulman, A.-P. Jauho, B. Xu, C. Joachim, C. Kergueris, E.G. Emberly, G.C. Liang, J. Heurich, J. Reichert, J. Taylor, J.M. Seminario, J.R. Heath, K. Walczak, K. Walczak, L.E. Hall, M. Ventra Di, M.A. Reed, P.S. Damle, S.E. Lyshevski, S.N. Yaliraki, S.T. Pantelides, W. Tian, Y. Wada, Y. Xue   +26 more
core   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Hierarchical mechanism of amino acid sensing by the T-box riboswitch

Nature Communications, 2018
Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution ...
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz, Nils G. Walter   +5 more
doaj   +1 more source