Results 231 to 240 of about 62,512 (285)

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

Yb2‐Tb Upconversion in a Hetero‐Trimetallic Molecular Lanthanide Complex

Angewandte Chemie, EarlyView.
Lanthanides are at the forefront of photon upconversion in molecular systems; however, the chemical nature of the lanthanides makes site‐specific coordination chemistry difficult to achieve. Here, we employ kinetically stabile building blocks to achieve hetero‐trimetallic 4f complexes with complete site‐specific chemical control.
Nicolaj Kofod, Matthew E. Thornton, Abigail Richardson, Charles Smith, Sabina Gurung, Patrick Parkinson, Stephen Faulkner, Sam Hay, Louise S. Natrajan   +8 more
wiley   +2 more sources

Interplay between conformational dynamics and substrate binding regulates enzymatic activity: a single-molecule FRET study. [PDF]

Chem Sci
Scheerer D, Levy D, Casier R, Riven I, Mazal H, Haran G.   +5 more
europepmc   +1 more source

Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the research process regarding skin defect repair using a rat model of skin defect. First, it assesses whether the barrier function of the skin is repaired. If the answer is “YES”, the study proceeds to focus on structural repair.
Cong Sun, Weihong Guo, Fang Liang, Rabia Javed, Weijian Hou, Xingdong Zhang, Qiang Ao   +6 more
wiley   +1 more source

Correction to 'RNase E searches for cleavage sites in RNA by linear diffusion: direct evidence from single-molecule FRET'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +1 more source

Distanzabhängiger Energietransfer zwischen organischen Fluorophoren und einwandigen Kohlenstoffnanoröhren

Angewandte Chemie, EarlyView.
Wir zeigen, dass hybridisierte dsDNA eine senkrechte Ausrichtung zu SWCNTs einnimmt, und präsentieren eine abstandsabhängige Übertragung der Energie von Fluoreszenzfarbstoffen auf SWCNTs. Der Energietransfer von Kohlenstoffnanoröhren (CNET) folgt einer d−5‐Abhängigkeit mit einem charakteristischen Abstand von 7,4 nm (± 0,7 nm) für 50 % Energietransfer.
Izabela Kamińska, Justus T. Metternich, Alan M. Szalai, Carolin Smidoda, Sayantani Chakraborty, Lela Vukovic, Sebastian Kruss, Philip Tinnefeld   +7 more
wiley   +1 more source

Au42(PET)32 Nanocluster Sensitizer Unlocks the Annihilator Potential of Rubrene, Enabling High‐Performance NIR‐to‐Visible Photon Upconversion

Angewandte Chemie, EarlyView.
A needle‐shaped gold nanocluster, Au42(PET)32, serves as a powerful triplet sensitizer, enabling rubrene to fully express its intrinsic annihilator capability (spin statistical factor f = 0.58). This sensitizer–annihilator pair achieves record‐high upconversion internal quantum yields of 21.4% (808 nm excitation) and 15.0% (936 nm excitation ...
Masaaki Mitsui, Shinjiro Takano, Tatsuya Tsukuda   +2 more
wiley   +1 more source