Results 221 to 230 of about 5,805,397 (279)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Reverse Haptic Alerting: Human‐Centered Intelligent Systems That Turn Chemical and Biomedical Signals Into Felt Cues

Advanced Intelligent Systems, EarlyView.
Wearable sensors usually warn through sight or sound, channels that become unreliable under protective equipment or in noise. Reverse haptic alerting inverts this flow: Stimuli‐responsive materials convert chemical and biological signals into cues felt through the skin, while a machine‐learned digital twin of tactile perception personalizes the body ...
Hwanhee Yoo, Shin Hum Cho, Ku Kang, Yoon Jeong Jang, Chan‐Mo Yang, Doo‐Hee Lee   +5 more
wiley   +1 more source

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +2 more sources

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

Angewandte Chemie, EarlyView.
Hydration switches photoinduced electron transfer (PET) ON in alkoxy‐coordinated BODIPY dyes via specific hydrogen bonding. This gating yields a fluorescence lifetime span of ∼6 ns, enabling fluorescence lifetime imaging microscopy (FLIM) contrast in live cells and organoids. ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are
Venkata N. K. Mamillapalli, Irina A. Okkelman, Fatima Akhssas, Greta Sambucari, Angela C. Debruyne, Dinesh Beniwal, Christophe Bucher, Mariangela Di Donato, Ruslan I. Dmitriev, Mikhail A. Filatov   +9 more
wiley   +2 more sources

Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget. [PDF]

Nat Commun
Miao Y, Cheng Y, Xia Y, Hei Y, Wang W, Dai Q, Suo J, Chen C.   +7 more
europepmc   +1 more source

Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor

Angewandte Chemie, EarlyView.
Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker, Hongyu Wang, Kun Chen, Kristin Löbner, Karin Mörl, Simon Jonas Schwarz, Qiang Zhao, Beili Wu, Annette Gabriele Beck‐Sickinger   +8 more
wiley   +2 more sources

Remote Electrostatic Effect between Octahedral Ru/Ir‐Complexes and Aromatic Micelles to Improve Their Photofunctions in Water

Angewandte Chemie, EarlyView.
The aqueous‐state encapsulation of cationic Ru(II)/Ir(III)‐complexes is efficiently demonstrated by anionic aromatic micelles via remote electrostatic interactions. The resulting host–guest composites exhibit enhanced metal‐complex‐based emission (∼3 to 10‐fold) and NIR emission through guest‐to‐guest FRET upon co‐encapsulation.
Rina Morooka, Yuya Tanaka, Michito Yoshizawa   +2 more
wiley   +2 more sources

RNase E searches for cleavage sites in RNA by linear diffusion: direct evidence from single-molecule FRET. [PDF]

Nucleic Acids Res
Banerjee T, Rothenberg E, Belasco JG.
europepmc   +1 more source

Efficient Green Light‐Induced Photoclick Reactions Enabled by Triplet–Triplet Annihilation Photon Upconversion

Angewandte Chemie, EarlyView.
A general strategy for 9,10‐phenanthrenequinone‐electron‐rich alkene (PQ‐ERA) photoclick reactions via triplet–triplet annihilation upconversion (TTA‐UC) under low‐intensity green light is reported. A TTA‐UC system of PdOEP (sensitizer) and DPA (annihilator) mixed with reactants generates UV/blue photons overlapping the absorption of PQ derivatives ...
Qingxin Luan, Mei Sang, Yuxin He, Hao Yang, Anna M. Doze, Lili Hou, Youxin Fu, Ben L. Feringa   +7 more
wiley   +2 more sources

Distinct PXR Inverse Agonism Mechanisms Rely on Differential Ligand‐induced Co‐Regulator Recruitment

Angewandte Chemie, EarlyView.
Pregnane X receptor (PXR) antagonism is ligand‐encoded: SPA70 recruits corepressors NCoR1 (nuclear receptor corepressor 1)/SMRT (silencing mediator for retinoid and thyroid‐hormone receptors) while binding coactivators, and is modulated by retinoid X receptor alpha (RXRα); MI891 causes cytoplasmic retention and corepressor‐dependent repression ...
Rajamanikkam Kamaraj, Azam Rashidian, Dharani Sai Sreekanth Nellore, Levi Miederer, Ivana Mejdr, Radim Nencka, Thales Kronenberger, Petr Pavek   +7 more
wiley   +2 more sources