Results 231 to 240 of about 5,805,397 (279)

Single-molecule FRET probes allosteric effects on protein-translocating pore loops of a AAA+ machine

, 2023
Iljina M, Mazal H, Dayananda A, Zhang Z, Stan G, Riven I, Haran G.   +6 more
europepmc   +1 more source

Single-molecule FRET probes allosteric effects on protein-translocating pore loops of a AAA+ machine. [PDF]

Biophys J
Iljina M, Mazal H, Dayananda A, Zhang Z, Stan G, Riven I, Haran G.   +6 more
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Synthesis of a Stable Hydrophilic trans‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

Angewandte Chemie International Edition, EarlyView.
A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov, Dina Osmanović, Ines Bašić, Christine Koehler, Paul F. Sauter   +4 more
wiley   +1 more source

Correction to 'RNase E searches for cleavage sites in RNA by linear diffusion: direct evidence from single-molecule FRET'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Enzyme activation by urea reveals the interplay between conformational dynamics and substrate binding: a single-molecule FRET study

Scheerer D, Levy D, Casier R, Riven I, Mazal H, Haran G.   +5 more
europepmc   +1 more source

Manipulating Protein Conformations by Single-Molecule AFM-FRET Nanoscopy [PDF]

ACS Nano, 2012
Combining atomic force microscopy and fluorescence resonance energy transfer spectroscopy (AFM-FRET), we have developed a single-molecule AFM-FRET nanoscopy approach capable of effectively pinpointing and mechanically manipulating a targeted dye-labeled ...
Maolin Lu, Peter Lu, Yufan He
exaly   +3 more sources

High-Resolution Single-Molecule FRET via DNA eXchange (FRET X)

Nano Letters, 2021
Single-molecule FRET is a versatile tool to study nucleic acids and proteins at the nanometer scale. However, currently, only a couple of FRET pairs can be reliably measured on a single object, which makes it difficult to apply single-molecule FRET for ...
Sung Hyun Kim, Mike Filius, Ivo Severins
exaly   +2 more sources

Single-Molecule Four-Color FRET [PDF]

Angewandte Chemie - International Edition, 2010
We developed a single-molecule four-color FRET technique both in confocal and in total-internal-reflection fluorescence microscopies. Real-time determination of six inter-fluorophore FRET efficiencies allowed us to probe the correlated motion of four arms of the Holliday junction.
Sanghwa Lee, Sungchul Hohng, Jingyi Fei
exaly   +3 more sources

Monitoring Multiple Distances Within a Single Molecule Using Switchable FRET

Nature Methods, 2010
Uphoff S, Holden SJ, Le Reste L, et al. Monitoring multiple distances within a single molecule using switchable FRET. NATURE METHODS. 2010;7(10):831-836.The analysis of structure and dynamics of biomolecules is important for understanding their function.
Stephan Uphoff, Seamus J. Holden, Sebastian van de Linde   +2 more
exaly   +2 more sources