Results 91 to 100 of about 1,316,697 (275)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Enhanced Single‐Particle Upconversion Imaging via Energy Migration Boosting

Advanced Science
Lanthanide‐doped upconversion nanoparticles (UCNPs) are promising bioimaging probes due to their exceptional photostability and minimal background interference. However, their limited single‐particle brightness has hindered broader applications.
Yanxin Zhang, Rongrong Wen, Tianli Zhai, Wenrui Zhang, Fan Ding, Huan Ling, Yunxiang Zhang, Qian Liu   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Multi-Dimensional Spectral Single Molecule Localization Microscopy

Frontiers in Bioinformatics, 2022
Single molecule localization (SML) and tracking (SPT) techniques, such as (spt)PALM, (u/DNA)PAINT and quantum dot tracking, have given unprecedented insight into the nanoscale molecular organization and dynamics in living cells.
Corey Butler, Corey Butler, G Ezequiel Saraceno, Adel Kechkar, Nathan Bénac, Vincent Studer, Julien P. Dupuis, Laurent Groc, Rémi Galland, Jean-Baptiste Sibarita   +9 more
doaj   +1 more source

Dragonfly: an implementation of the expand–maximize–compress algorithm for single-particle imaging

Journal of Applied Crystallography, 2016
A description is given of a single-particle X-ray imaging reconstruction and simulation package using the expand–maximize–compress algorithm, named Dragonfly.
K. Ayyer, Ti-Yen Lan, V. Elser, N. D. Loh   +3 more
semanticscholar   +1 more source

Low-signal limit of X-ray single particle diffractive imaging. [PDF]

Optics Express, 2019
An outstanding question in X-ray single particle imaging experiments has been the feasibility of imaging sub 10-nm-sized biomolecules under realistic experimental conditions where very few photons are expected to be measured in a single snapshot and ...
Artik, Yyer, Ndrew, M. J., Organ, Quila, Asan, Irci, Renda, H. G., Ogue, Ichard, A., Irian, L. P., Ourdu, Avier, Hun, Ong, Oon, enry, N., Hapman, Ntón, Arty   +24 more
semanticscholar   +1 more source

Single particle tracking uncertainties in ion imaging

, 2020
19 pages, 6 figures, submitted to Phys.
Burker, A., Bergauer, T., Hirtl, A., Irmler, C., Kaser, S., Knäusl, B., Pitters, F., Ulrich-Pur, F.   +7 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

4D Scanning Transmission Ultrafast Electron Microscopy: Single-Particle Imaging and Spectroscopy [PDF]

, 2011
We report the development of 4D scanning transmission ultrafast electron microscopy (ST-UEM). The method was demonstrated in the imaging of silver nanowires and gold nanoparticles.
Ortalan, Volkan, Zewail, Ahmed H.
core  

Talbot Oscillations and Periodic Focusing in a One-Dimensional Condensate

, 1999
An exact theory for the density of a one-dimensional Bose-Einstein condensate with hard core particle interactions is developed in second quantization and applied to the scattering of the condensate by a spatially periodic impulse potential.
A. G. Rojo, A. Lenard, B. Dubetsky, C. C. Bradley, D. G. Fried, D. M. Giltner, D. W. Keith, E. M. Rasel, G. Timp, H. F. Talbot, J. J. McClelland, J. Javanainen, J. Javanainen, J. L. Cohen, K. B. Davis, K. G. Singh, K. Patorski, M. Edwards, M. Edwards, M. Girardeau, M. H. Anderson, M. Kozuma, M. Lewenstein, M. S. Chapman, M.-O. Mewes, P. E. Moskowitz, P. R. Berman, P. Zoller, R. Penrose, S. Cahn, T. Sleator, T. T. Chou, U. Janicke   +32 more
core   +1 more source