Results 31 to 40 of about 495,951 (309)

Reference-enhanced X-ray single-particle imaging

Acta Crystallographica Section A Foundations and Advances, 2023
Abhishek Mall, Kartik Ayyer
openalex   +2 more sources

The role of transient resonances for ultra-fast imaging of single sucrose nanoclusters

Nature Communications, 2020
X-ray free electron lasers provide high photon flux to explore single particle diffraction imaging of biological samples. Here the authors present dynamic electronic structure calculations and benchmark them to single-particle XFEL diffraction data of ...
Phay J. Ho, Benedikt J. Daurer, Max F. Hantke, Johan Bielecki, Andre Al Haddad, Maximilian Bucher, Gilles Doumy, Ken R. Ferguson, Leonie Flückiger, Tais Gorkhover, Bianca Iwan, Christopher Knight, Stefan Moeller, Timur Osipov, Dipanwita Ray, Stephen H. Southworth, Martin Svenda, Nicusor Timneanu, Anatoli Ulmer, Peter Walter, Janos Hajdu, Linda Young, Filipe R. N. C. Maia, Christoph Bostedt   +23 more
doaj   +1 more source

3D printed devices and infrastructure for liquid sample delivery at the European XFEL

Journal of Synchrotron Radiation, 2022
The Sample Environment and Characterization (SEC) group of the European X-ray Free-Electron Laser (EuXFEL) develops sample delivery systems for the various scientific instruments, including systems for the injection of liquid samples that enable serial ...
Mohammad Vakili, Johan Bielecki, Juraj Knoška, Florian Otte, Huijong Han, Marco Kloos, Robin Schubert, Elisa Delmas, Grant Mills, Raphael de Wijn, Romain Letrun, Simon Dold, Richard Bean, Adam Round, Yoonhee Kim, Frederico A. Lima, Katerina Dörner, Joana Valerio, Michael Heymann, Adrian P. Mancuso, Joachim Schulz   +20 more
doaj   +1 more source

Tracking Image Correlation: Combining Single-Particle Tracking and Image Correlation [PDF]

Biophysical Journal, 2013
The interactions and coordination of biomolecules are crucial for most cellular functions. The observation of protein interactions in live cells may provide a better understanding of the underlying mechanisms. After fluorescent labeling of the interacting partners and live-cell microscopy, the colocalization is generally analyzed by quantitative global
Dupont, A., Stirnnagel, K., Lindemann, D., Lamb, D.C.   +3 more
openaire   +2 more sources

Modular Imaging Scaffold for Single-Particle Electron Microscopy

ACS Nano, 2021
Technological breakthroughs in electron microscopy (EM) have made it possible to solve structures of biological macromolecular complexes and to raise novel challenges, specifically related to sample preparation and heterogeneous macromolecular assemblies such as DNA-protein, protein-protein, and membrane protein assemblies.
Aissaoui, Nesrine, Him, Josephine Lai Kee, Mills, Allan, Declerck, Nathalie, Morichaud, Zakia, Brodolin, Konstantin, Baconnais, Sonia, Le Cam, Eric, Charbonnier, Jean-Baptiste, Sounier, Rémy, Granier, Sébastien, Ropars, Virginie, Bron, Patrick, Bellot, Gaetan   +13 more
openaire   +5 more sources

Emerging Themes in CryoEM─Single Particle Analysis Image Processing

Chemical Reviews, 2022
Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is an interdisciplinary field that takes advantage of advances in biochemistry, physics, and image processing, among other disciplines. Innovations in these three basic pillars have contributed to the boosting of CryoEM in the past decade.
Vilas, Jose Luis, Carazo, Jose Maria, Sorzano, Carlos Oscar S.   +2 more
openaire   +2 more sources

Structural Heterogeneity in Single Particle Imaging Using X-ray Lasers. [PDF]

J Phys Chem Lett, 2020
One of the challenges facing single particle imaging with ultrafast X-ray pulses is the structural heterogeneity of the sample to be imaged. For the method to succeed with weakly scattering samples, the diffracted images from a large number of individual proteins need to be averaged.
Mandl T, Östlin C, Dawod IE, Brodmerkel MN, Marklund EG, Martin AV, Timneanu N, Caleman C.   +7 more
europepmc   +7 more sources

Microlens-Assisted Light-Scattering Imaging of Plasmonic Nanoparticles at the Single Particle Level

Biosensors, 2023
We present a microlens-assisted imaging approach to record the scattering light of plasmonic nanoparticles at the single particle level. The microlens can significantly enhance the backscattering of visible light from individual plasmonic nanoparticles ...
Pengcheng Zhang, Tingting Zhan, Sha Xue, Hui Yang   +3 more
doaj   +1 more source

Digital detection of biomarkers for low-cost, high-sensitivity diagnostics [PDF]

, 2016
We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral ...
Ünlü, M. Selim
core   +1 more source

MRI detection of single particles for cellular imaging [PDF]

Proceedings of the National Academy of Sciences, 2004
There is rapid growth in the use of MRI for molecular and cellular imaging. Much of this work relies on the high relaxivity of nanometer-sized, ultrasmall dextran-coated iron oxide particles. Typically, millions of dextran-coated ultrasmall iron oxide particles must be loaded into cells for efficient detection.
Shapiro, EM, Skrtic, S, Sharer, K, Hill, JM, Dunbar, CE, Koretsky, AP   +5 more
openaire   +3 more sources