Results 21 to 30 of about 173,038 (236)

Is radiation damage the limiting factor in high-resolution single particle imaging with X-ray free-electron lasers? [PDF]

Structural Dynamics, 2019
The prospect of single particle imaging with atomic resolution is one of the scientific drivers for the development of X-ray free-electron lasers. The assumption since the beginning has been that damage to the sample caused by intense X-ray pulses is one
C. Östlin, N. Timneanu, C. Caleman, A. V. Martin   +3 more
doaj   +2 more sources

Single-particle imaging of nanomedicine entering the brain. [PDF]

Proc Natl Acad Sci U S A
Nanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano–neuro interaction are elusive. In particular, whether nanocarriers can cross the blood–brain barrier (BBB) and release the drug cargo inside the brain, a basic process depicted in numerous books and reviews, remains controversial.
Wei M, Qian N, Gao X, Lang X, Song D, Min W.   +5 more
europepmc   +3 more sources

Biological single-particle imaging using XFELs – towards the next resolution revolution [PDF]

IUCrJ, 2018
Dominik Oberthür
doaj   +2 more sources

Single Particle X-ray Diffractive Imaging [PDF]

Nano Letters, 2007
In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas phase are critically important for surface modification and substrate-free characterization. Recent coherent diffractive imaging with intense femtosecond X-ray pulses has verified the capability of single-shot imaging of nanoscale objects at suboptical ...
Bogan, M. J., Benner, W. H., Boutet, S., Rohner, U., Frank, M., Seibert, M., Maia, F., Barty, A., Bajt, S., Riot, V., Woods, B., Marchesini, S., Hau-Riege, S. P., Svenda, M., Marklund, E., Spiller, E., Hajdu, J., Chapman, H. N.   +17 more
openaire   +3 more sources

MRI detection of single particles for cellular imaging [PDF]

Proceedings of the National Academy of Sciences, 2004
There is rapid growth in the use of MRI for molecular and cellular imaging. Much of this work relies on the high relaxivity of nanometer-sized, ultrasmall dextran-coated iron oxide particles. Typically, millions of dextran-coated ultrasmall iron oxide particles must be loaded into cells for efficient detection.
Shapiro, EM, Skrtic, S, Sharer, K, Hill, JM, Dunbar, CE, Koretsky, AP   +5 more
openaire   +3 more sources

A reconstruction algorithm for single-particle diffraction imaging experiments [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2009
52 pages, 17 figures and uses algorithm2e package v4: split first section into 2.
Loh, Duane Ne-Te, Elser, Veit
openaire   +4 more sources

The role of transient resonances for ultra-fast imaging of single sucrose nanoclusters

Nature Communications, 2020
X-ray free electron lasers provide high photon flux to explore single particle diffraction imaging of biological samples. Here the authors present dynamic electronic structure calculations and benchmark them to single-particle XFEL diffraction data of ...
Phay J. Ho, Benedikt J. Daurer, Max F. Hantke, Johan Bielecki, Andre Al Haddad, Maximilian Bucher, Gilles Doumy, Ken R. Ferguson, Leonie Flückiger, Tais Gorkhover, Bianca Iwan, Christopher Knight, Stefan Moeller, Timur Osipov, Dipanwita Ray, Stephen H. Southworth, Martin Svenda, Nicusor Timneanu, Anatoli Ulmer, Peter Walter, Janos Hajdu, Linda Young, Filipe R. N. C. Maia, Christoph Bostedt   +23 more
doaj   +1 more source

3D printed devices and infrastructure for liquid sample delivery at the European XFEL

Journal of Synchrotron Radiation, 2022
The Sample Environment and Characterization (SEC) group of the European X-ray Free-Electron Laser (EuXFEL) develops sample delivery systems for the various scientific instruments, including systems for the injection of liquid samples that enable serial ...
Mohammad Vakili, Johan Bielecki, Juraj Knoška, Florian Otte, Huijong Han, Marco Kloos, Robin Schubert, Elisa Delmas, Grant Mills, Raphael de Wijn, Romain Letrun, Simon Dold, Richard Bean, Adam Round, Yoonhee Kim, Frederico A. Lima, Katerina Dörner, Joana Valerio, Michael Heymann, Adrian P. Mancuso, Joachim Schulz   +20 more
doaj   +1 more source

Prospects for single-particle imaging at XFELs [PDF]

Digest of the LEOS Summer Topical Meetings Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004., 2004
X-ray free-electron lasers will produce pulses of X-rays that are 10 orders of magnitude brighter than today's undulator sources at synchrotrons. This may enable atomic resolution imaging of single macromolecules.
Chapman, H N, Hau-Riege, S P, London, R A, Marchesini, S, Noy, A, Szoke, A, Szoke, H, Ingerman, E, Hajdu, J, Huldt, G, Howells, M R, He, H, Spence, J H, Weierstall, U   +13 more
openaire   +1 more source

Modular Imaging Scaffold for Single-Particle Electron Microscopy

ACS Nano, 2021
Technological breakthroughs in electron microscopy (EM) have made it possible to solve structures of biological macromolecular complexes and to raise novel challenges, specifically related to sample preparation and heterogeneous macromolecular assemblies such as DNA-protein, protein-protein, and membrane protein assemblies.
Aissaoui, Nesrine, Him, Josephine Lai Kee, Mills, Allan, Declerck, Nathalie, Morichaud, Zakia, Brodolin, Konstantin, Baconnais, Sonia, Le Cam, Eric, Charbonnier, Jean-Baptiste, Sounier, Rémy, Granier, Sébastien, Ropars, Virginie, Bron, Patrick, Bellot, Gaetan   +13 more
openaire   +5 more sources