Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser [PDF]
IUCrJ, 2017 Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules.
Carsten Fortmann-Grote +12 more
doaj +2 more sources
Is radiation damage the limiting factor in high-resolution single particle imaging with X-ray free-electron lasers? [PDF]
Structural Dynamics, 2019 The prospect of single particle imaging with atomic resolution is one of the scientific drivers for the development of X-ray free-electron lasers. The assumption since the beginning has been that damage to the sample caused by intense X-ray pulses is one
C. Östlin +3 more
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Single-particle imaging of nanomedicine entering the brain. [PDF]
Proc Natl Acad Sci U S ANanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano–neuro interaction are elusive. In particular, whether nanocarriers can cross the blood–brain barrier (BBB) and release the drug cargo inside the brain, a basic process depicted in numerous books and reviews, remains controversial.
Wei M +5 more
europepmc +3 more sources
Biological single-particle imaging using XFELs – towards the next resolution revolution [PDF]
IUCrJ, 2018 Dominik Oberthür
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Single Particle X-ray Diffractive Imaging [PDF]
Nano Letters, 2007 In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas phase are critically important for surface modification and substrate-free characterization. Recent coherent diffractive imaging with intense femtosecond X-ray pulses has verified the capability of single-shot imaging of nanoscale objects at suboptical ...
Bogan, M. J. +17 more
openaire +3 more sources
MRI detection of single particles for cellular imaging [PDF]
Proceedings of the National Academy of Sciences, 2004 There is rapid growth in the use of MRI for molecular and cellular imaging. Much of this work relies on the high relaxivity of nanometer-sized, ultrasmall dextran-coated iron oxide particles. Typically, millions of dextran-coated ultrasmall iron oxide particles must be loaded into cells for efficient detection.
Shapiro, EM +5 more
openaire +3 more sources
A reconstruction algorithm for single-particle diffraction imaging experiments [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2009 52 pages, 17 figures and uses algorithm2e package v4: split first section into 2.
Loh, Duane Ne-Te, Elser, Veit
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The role of transient resonances for ultra-fast imaging of single sucrose nanoclusters
Nature Communications, 2020 X-ray free electron lasers provide high photon flux to explore single particle diffraction imaging of biological samples. Here the authors present dynamic electronic structure calculations and benchmark them to single-particle XFEL diffraction data of ...
Phay J. Ho +23 more
doaj +1 more source
Isotropic resolution in fluorescence imaging by single particle reconstruction [PDF]
2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), 2016 Low axial resolution is a major limitation of fluorescence imaging modalities. We propose a methodology to achieve high isotropic resolution by reconstructing fluorescence volumes from observations of multiple particle replicates with different orientations.
Fortun, D. +3 more
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3D printed devices and infrastructure for liquid sample delivery at the European XFEL
Journal of Synchrotron Radiation, 2022 The Sample Environment and Characterization (SEC) group of the European X-ray Free-Electron Laser (EuXFEL) develops sample delivery systems for the various scientific instruments, including systems for the injection of liquid samples that enable serial ...
Mohammad Vakili +20 more
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