Water layer and radiation damage effects on the orientation recovery of proteins in single-particle imaging at an X-ray free-electron laser [PDF]
Scientific Reports, 2023 The noise caused by sample heterogeneity (including sample solvent) has been identified as one of the determinant factors for a successful X-ray single-particle imaging experiment.
Juncheng E +8 more
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Ultrafast Single-Particle Imaging with Intense X-Ray Pulses
CHIMIA, 2022 Ultrafast single-particle imaging with intense x-ray pulses from free-electron laser sources provides a new approach for visualizing structure and dynamics on the nanoscale. After a short introduction to the novel free-electron laser sources and methods,
Zhibin Sun +6 more
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Evaluation of the performance of classification algorithms for XFEL single-particle imaging data [PDF]
IUCrJ, 2019 Using X-ray free-electron lasers (XFELs), it is possible to determine three-dimensional structures of nanoscale particles using single-particle imaging methods.
Yingchen Shi +12 more
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A predicted model-aided one-step classification–multireconstruction algorithm for X-ray free-electron laser single-particle imaging [PDF]
IUCrJUltrafast, high-intensity X-ray free-electron lasers can perform diffraction imaging of single protein molecules. Various algorithms have been developed to determine the orientation of each single-particle diffraction pattern and reconstruct the 3D ...
Zhichao Jiao, Zhi Geng, Wei Ding
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Recovery of undamaged electron-density maps in the presence of damage-induced partial coherence in single-particle imaging [PDF]
IUCrJ, 2020 Resolving the electronic structure of single biological molecules in their native state was among the primary motivations behind X-ray free-electron lasers. The ultra-short pulses they produce can outrun the atomic motion induced by radiation damage, but
Alexander Kozlov +5 more
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Effects of radiation damage and inelastic scattering on single-particle imaging of hydrated proteins with an X-ray Free-Electron Laser [PDF]
Scientific Reports, 2021 We present a computational case study of X-ray single-particle imaging of hydrated proteins on an example of 2-Nitrogenase–Iron protein covered with water layers of various thickness, using a start-to-end simulation platform and experimental parameters ...
Juncheng E +7 more
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A predicted model-aided reconstruction algorithm for X-ray free-electron laser single-particle imaging [PDF]
IUCrJUltra-intense, ultra-fast X-ray free-electron lasers (XFELs) enable the imaging of single protein molecules under ambient temperature and pressure.
Zhichao Jiao +5 more
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Surface chemistry and morphology in single particle optical imaging
Nanophotonics, 2017 Biological nanoparticles such as viruses and exosomes are important biomarkers for a range of medical conditions, from infectious diseases to cancer. Biological sensors that detect whole viruses and exosomes with high specificity, yet without additional ...
Ekiz-Kanik Fulya +4 more
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IUCrJ, 2017 Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules.
Carsten Fortmann-Grote +12 more
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Efficient Lithium-Based Upconversion Nanoparticles for Single-Particle Imaging and Temperature Sensing. [PDF]
Materials (Basel), 2023 Alzahrani YA, Alromaeh A, Alkahtani M.
europepmc +2 more sources