Results 51 to 60 of about 1,316,697 (275)

Digital detection of biomarkers for low-cost, high-sensitivity diagnostics [PDF]

, 2016
We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral ...
Ünlü, M. Selim
core   +1 more source

MRI detection of single particles for cellular imaging [PDF]

Proceedings of the National Academy of Sciences, 2004
There is rapid growth in the use of MRI for molecular and cellular imaging. Much of this work relies on the high relaxivity of nanometer-sized, ultrasmall dextran-coated iron oxide particles. Typically, millions of dextran-coated ultrasmall iron oxide particles must be loaded into cells for efficient detection.
Shapiro, EM, Skrtic, S, Sharer, K, Hill, JM, Dunbar, CE, Koretsky, AP   +5 more
openaire   +3 more sources

The influence of movement on the localization precision of sub-resolution particles in fluorescence microscopy [PDF]

, 2011
Obtaining sub-resolution particle positions in fluorescence microscopy images is essential for single particle tracking and high-resolution localization microscopy.
Braeckmans, Kevin, Deschout, Hendrik, Neyts, Kristiaan   +2 more
core   +1 more source

Single Particle Imaging with FEL Using Photon Correlations [PDF]

, 2020
AbstractScattering experiments with femtosecond high-intensity free-electron laser pulses provide a new route to macromolecular structure determination without the need for crystallization at low material usage. In these experiments, the X-ray pulses are scattered with high repetition on a stream of identical single biomolecules and the scattered ...
von Ardenne, Benjamin, Grubmüller, Helmut, Salditt, Tim, Egner, Alexander, Luke, D. Russell   +4 more
openaire   +4 more sources

Single-molecule and particle detection on true portable microscopy platforms

Sensors and Actuators Reports, 2022
Point-of-care technologies (POCT) that enable early disease detection and therapeutic monitoring are crucial for the next generation of diagnostics and personalized medicine.
Lydia Skolrood, Yan Wang, Shengwei Zhang, Qingshan Wei   +3 more
doaj   +1 more source

High-resolution Imaging of nanoparticles in wide-field interferometric scattering microscopy [PDF]

, 2019
Single particle interferometric scattering microscopy has demonstrated great capability in label-free imaging of sub-wavelength dielectric nanoparticles ...
Avci, Oguzhan, Matlock, Alex, Ozbay, Ekmel, Tian, Lei, Yurdakul, Celalettin, Ünlü, M. Selim   +5 more
core   +1 more source

Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications [PDF]

, 2013
Hyperspectral microscopy is a versatile method for simultaneous spatial and spectroscopic characterization of nonfluorescent samples. Here we present a hyperspectral darkfield imaging system for spectral imaging of single nanoparticles over an area of ...
Acimovic, Agathi Christofidou, Alkilany, Ament, Anker, Antonios G. Kanaras, Arvizo, Barreto, Bartczak, Becker, Bingham, Brown, Dreaden, Erathodiyil, Grabinski, Hutter, Johnson, Jun, Krpetic, Lassiter, Michalet, Mock, Murray, Natasha Fairbairn, Otto L. Muskens, Parak, Rosman, Saha, Schwartzberg, Sonnichsen, Tracey A. Newman, Urban, Van Dijk, Wu, Xie, Zhang, Zhang, Zhao   +37 more
core   +1 more source

Stripe sensor tomography [PDF]

, 2008
We introduce a general concept of tomographic imaging for the case of an imaging sensor that has a stripelike shape. We first show that there is no difference, in principle, between two-dimensional tomography using conventional electromagnetic or ...
Barbic, Mladen, Barrett, Christopher P., Emery, Teresa H., Scherer, Axel, Vitava, Lvcian   +4 more
core   +1 more source

Surface chemistry and morphology in single particle optical imaging

Nanophotonics, 2017
Biological nanoparticles such as viruses and exosomes are important biomarkers for a range of medical conditions, from infectious diseases to cancer. Biological sensors that detect whole viruses and exosomes with high specificity, yet without additional ...
Ekiz-Kanik Fulya, Sevenler Derin Deniz, Ünlü Neşe Lortlar, Chiari Marcella, Ünlü M. Selim   +4 more
doaj   +1 more source

Prospects for single-particle imaging at XFELs [PDF]

Digest of the LEOS Summer Topical Meetings Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004., 2004
X-ray free-electron lasers will produce pulses of X-rays that are 10 orders of magnitude brighter than today's undulator sources at synchrotrons. This may enable atomic resolution imaging of single macromolecules.
Chapman, H N, Hau-Riege, S P, London, R A, Marchesini, S, Noy, A, Szoke, A, Szoke, H, Ingerman, E, Hajdu, J, Huldt, G, Howells, M R, He, H, Spence, J H, Weierstall, U   +13 more
openaire   +1 more source