Results 31 to 40 of about 15,513 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Novo conversor CC-CA elevador-abaixador de tensão [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2013Esta tese apresenta uma nova topologia para os conversores CC-CA, que possibilita obter uma tensão ...
Piazza, Gleyson Luiz
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Single-Sourced Double-Stage Multilevel Inverter for Grid-Connected Solar PV Systems

IEEE Open Journal of the Industrial Electronics Society, 2022
Design challenges for grid-connected solar photovoltaic systems related to the power conditioning units are power quality, efficiency, reliability, cost of implementation, etc.
Neha Tak, Sumit K. Chattopadhyay, Chandan Chakraborty   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Torque behavior of one-phase permanent magnet AC motor [PDF]

, 2006
This paper presents a detailed comparative study of two starting and running methods for a single-phase permanent magnet synchronous motor, equipped with a squirrel-cage rotor. The analysis of the motor performance is realized for a pulse width modulated
McGilp, M.I., Miller, T.J.E., Trivillin, N., Strappazzon, G., Popescu, M., Santarossa, R.   +5 more
core   +1 more source

Derivation of OCC Modulator for Grid-Tied Single-Stage Buck-Boost Inverter Operating in the Discontinuous Conduction Mode

Energies, 2020
This paper is concerned with the derivation of a one-cycle controller for driving a single-stage buck-boost DC-AC micro-inverter in grid-tied applications.
Ben Zhao, Yigeng Huangfu, Alexander Abramovitz   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Desain Dan Implementasi Single Stage Boost Inverter [PDF]

, 2015
Perkembangan teknologi yang berkaitan dengan pembangkitan menggunakan energi alternatif kini menjadi topik utama sebagai sumber energi yang digunakan pada sistem pembangkitan tersebar.
Huda, Moch Nurul
core  

Single-phase H-bridge inverter.

, 2019
Single-phase H-bridge inverter.
M. A. M. Radzi (4452457), M. Izadi (6944879), N. H. Zaini (6944885), M. Z. A. Ab-Kadir (6944876), N. I. Ahmad (6944882), M. S. M. Nasir (6944873)   +5 more
core   +1 more source