Results 211 to 220 of about 852,815 (296)

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

In Silico Ligand-Based Screening of PDB Database for Searching Unique Motifs Against SARS-CoV-2. [PDF]

Biomolecules
Machulin AV, Badaeva JV, Grishin SY, Deryusheva EI, Galzitskaya OV.   +4 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly. [PDF]

Nat Commun
König J, Sarmiento Alam NC, He R, Blömeke N, Sieluzycka O, Rührnößl F, Riedl M, Reif B, Feige MJ, Buchner J.   +9 more
europepmc   +1 more source

Adaptive Hydrogels With Spatiotemporal Stiffening Using pH‐Modulating Enzymes

Advanced Functional Materials, EarlyView.
The chemomechanical coupling in an adaptive hydrogel is studied to further the development of adaptive hydrogels. This coupling is achieved by embedding a pH‐modulating enzyme in a pH‐responsive hydrogel. The enzymatic reaction can be triggered locally, which generates a pH‐decreasing wave throughout the system, increasing the crosslinking density and ...
Natascha Gray, Zoe Grämiger, André R. Studart, Rafael Libanori   +3 more
wiley   +1 more source

Cargo Recognition of Nesprin-2 by the Dynein Adapter Bicaudal D2 for a Nuclear Positioning Pathway That Is Important for Brain Development. [PDF]

Biochemistry
Rodriguez Castro ED, Putta S, Ali MY, Garcia Martin JM, Zhao X, Sylvain S, Trybus KM, Solmaz SR.   +7 more
europepmc   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue. [PDF]

Nat Commun
Maun HR, Azumaya CM, Walters BT, Vij R, Morando A, Loyet KM, Koerber JT, Rohou A, Lazarus RA.   +8 more
europepmc   +1 more source

Regulated Ion‐Diffusion Hydrogels for Subtle and Multimodal Temperature‐Strain Sensing in Wound Monitoring

Advanced Functional Materials, EarlyView.
A soft, dual‐channel hydrogel patch enables simultaneous detection of wound temperature and strain by integrating ion‐diffusion‐mediated thermoelectric and resistive sensing. The conformal design maintains stable performance during motion, capturing subtle inflammatory and mechanical changes for continuous wound monitoring.
Yu Fang, Xinglong Pan, Zhiwei Li, Wanheng Lu, Chang Liu, Yi Zhou, Guo Tian, Ghim Wei Ho   +7 more
wiley   +1 more source

Gatekeeping Dietary Fiber: The Role of Carbohydrate-Binding Modules in the Human Gut. [PDF]

J Microbiol Biotechnol
Siziya IN, Park CS, Jung DH.
europepmc   +1 more source