Results 261 to 270 of about 837,611 (284)

Prospective Applications of Single-Domain Antibodies in Biomedicine

Molecular Biology, 2020
Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine.
openaire   +2 more sources

Expression of single-domain antibody in different systems

Applied Microbiology and Biotechnology, 2017
Camelid single-domain antibodies (sdAbs, VHHs, or Nanobodies®) are types of antibody fragments that are composed of the heavy-chain variable domain only. These VHHs possess unique structural and functional features, as they are small in size and exhibit thermal stability and high solubility. Compared to conventional antibodies, VHHs can be manufactured
Yongkang, Liu, He, Huang
openaire   +2 more sources

Bispecific Single Domain Antibodies

2011
Monoclonal antibodies are now widely recognized as therapeutic molecules and more than 25 molecules have been approved in the United States and other countries. Despite these successes, the clinical activity of these molecules is still far from optimal and new solutions have to be found, especially in the field of cancer therapy.
Patrick Chames, Daniel Baty
openaire   +1 more source

Characterization of Single-Domain Antibodies with an Engineered Disulfide Bond

2012
Camelidae single-domain antibodies (VHHs) represent a unique class of emerging therapeutics. Similar to other recombinant antibody fragments (e.g., Fabs, scFvs), VHHs are amenable to library screening and selection, but benefit from superior intrinsic biophysical properties such as high refolding efficiency, high solubility, no tendency for aggregation,
Hussack, G., MacKenzie, C.R., Tanha, J.
openaire   +3 more sources

Single domain antibodies

2006
Classical antibodies are complex assemblies, difficult to produce in bacteria, and too bulky for many medical or research applications. Therefore, substantial efforts aimed at finding simpler miniaturised antibodies. Heavy-chain antibodies in camelids are a natural source of such mini-antibodies. Moreover, their antigen-binding domain (named Nanobody),
openaire   +1 more source

[Progress in shark single-domain antibody].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2020
Monoclonal antibody (mAb) is an important biological macromolecule and widely used in immune detection, in vitro diagnostics, and drug discovery. However, the inherent properties of mAb restrict its further development, such as high molecular weight and complex structure. Therefore, there is an urgent need to develop alternatives for mAb. Various types
Xing, Liu, Qi, Chen
openaire   +1 more source

Single-Domain Antibodies

2022
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Identification of Human Single-Domain Antibodies against SARS-CoV-2

Cell Host and Microbe, 2020
Yanling Wu, Cheng Li, Shuai Xia
exaly  

Development of a platform process for the production and purification of single‐domain antibodies

Biotechnology and Bioengineering, 2021
Laura Ellen Crowell, Neil C Dalvie, Viviana Parreño   +2 more
exaly  

Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

EMBO Molecular Medicine, 2020
Elena Barbon, Charlotte Kawecki, Caterina Casari   +2 more
exaly