Results 241 to 250 of about 837,611 (284)

AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia. [PDF]

Theranostics
Vandewalle N, Satilmis H, Verheye E, Fan R, Wang Y, De Groof TWM, Bridoux J, Kerre T, De Beule N, De Becker A, De Bruyne E, Menu E, Vanderkerken K, Breckpot K, Devoogdt N, De Veirman K.   +15 more
europepmc   +1 more source

Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Willliamson DJ, Zaza C, Carlon-Andres I, Gentili A, Daly JL, Holmes H, Thrush JW, Starling T, Neil S, Owens R, Malim MH, Tynan C, Simoncelli S, Padilla-Parra S.   +13 more
europepmc   +1 more source

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. [PDF]

J Biol Chem
Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E.   +14 more
europepmc   +1 more source

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA). [PDF]

Infect Immun
Vance DJ, Basir S, Piazza CL, Willsey GG, Haque HME, Tremblay JM, Rudolph MJ, Muriuki B, Cavacini L, Weis DD, Shoemaker CB, Mantis NJ.   +11 more
europepmc   +1 more source

Isolation of camel single domain antibodies against Yersinia pestis V270 antigen based on a semi-synthetic single domain antibody library and development of a VHH-based lateral flow assay. [PDF]

Vet Med Sci
Wang B, Wang C, Li B, Yang J, Lin P, Jin X, Niu Y, Zhang W, Zhang X, Huang Y.   +9 more
europepmc   +1 more source

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Nanobodies: Natural Single-Domain Antibodies

Annual Review of Biochemistry, 2013
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
Serge V Muyldermans
exaly   +4 more sources

Single-Domain Antibody Theranostics on the Horizon

Journal of Nuclear Medicine, 2022
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic ...
Weijun, Wei, Muhsin H, Younis, Xiaoli, Lan, Jianjun, Liu, Weibo, Cai   +4 more
openaire   +2 more sources

Single domain camel antibodies: current status

Reviews in Molecular Biotechnology, 2001
The antigen-binding capacity of the paired variable domains of an antibody is well established. The observation that the isolated heavy chains of anti-hapten antibodies retain some antigen-binding capacity in the absence of light chains led to attempts to obtain an even smaller antigen-binding unit in a VH format.
Serge V Muyldermans
exaly   +4 more sources

Single-Domain Antibodies or Nanobodies: A Class of Next-Generation Antibodies

International Reviews of Immunology, 2018
Nanobodies for the first time were identified in the sera of Camelidae. Single-domain antibodies or nanobodies are a class of next-generation antibodies that have specific features: small size (in nanoscale), high penetration in various tissues, high stability in hard situations and ease production process in microbial systems.
Farnaz Khodabakhsh, Mahdi Behdani, Abbas Rami   +2 more
exaly   +3 more sources

Single-domain antibodies

2009
The antigen-binding entity of an antibody, reduced in size to one single domain, is referred to as a "single-domain antibody". Various strategies have been explored with variable success to arrive at functional sinlge-domain antibodies. The potential of single-domain antibodies, as research tools or in medicine, is reflected by the three companies ...
Muyldermans, Serge, Hassanzadeh Ghassabeh, Gholamreza, Saerens, Dirk   +2 more
openaire   +3 more sources