Results 241 to 250 of about 594,568 (282)

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. [PDF]

J Biol Chem
Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E.   +14 more
europepmc   +1 more source

Single-domain antibodies for biomedical applications [PDF]

Immunopharmacology and Immunotoxicology, 2016
Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding.
Simon Krah, Christian Schröter, Stefan Zielonka   +2 more
exaly   +5 more sources

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Nanobodies: Natural Single-Domain Antibodies

Annual Review of Biochemistry, 2013
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
Serge Muyldermans
exaly   +4 more sources

Single-Domain Antibody Theranostics on the Horizon

Journal of Nuclear Medicine, 2022
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic ...
Weijun, Wei, Muhsin H, Younis, Xiaoli, Lan, Jianjun, Liu, Weibo, Cai   +4 more
openaire   +2 more sources

Single domain camel antibodies: current status

Reviews in Molecular Biotechnology, 2001
The antigen-binding capacity of the paired variable domains of an antibody is well established. The observation that the isolated heavy chains of anti-hapten antibodies retain some antigen-binding capacity in the absence of light chains led to attempts to obtain an even smaller antigen-binding unit in a VH format.
Serge Muyldermans
exaly   +4 more sources

Single-Domain Antibodies or Nanobodies: A Class of Next-Generation Antibodies

International Reviews of Immunology, 2018
Nanobodies for the first time were identified in the sera of Camelidae. Single-domain antibodies or nanobodies are a class of next-generation antibodies that have specific features: small size (in nanoscale), high penetration in various tissues, high stability in hard situations and ease production process in microbial systems.
Farnaz Khodabakhsh, , Abbas Rami
exaly   +3 more sources

Single-domain antibodies

2009
The antigen-binding entity of an antibody, reduced in size to one single domain, is referred to as a "single-domain antibody". Various strategies have been explored with variable success to arrive at functional sinlge-domain antibodies. The potential of single-domain antibodies, as research tools or in medicine, is reflected by the three companies ...
Muyldermans, Serge, Hassanzadeh Ghassabeh, Gholamreza, Saerens, Dirk   +2 more
openaire   +3 more sources

Single-domain antibodies applied as antiviral immunotherapeutics

Journal of Virological Methods, 2023
Viral infections have been the cause of high mortality rates throughout different periods in history. Over the last two decades, outbreaks caused by zoonotic diseases and transmitted by arboviruses have had a significant impact on human health. The emergence of viral infections in different parts of the world encourages the search for new inputs to ...
Nidiane Dantas Reis, Prado, Nairo, Brilhante-Da-Silva, Rosa Maria Oliveira, Sousa, Michelle Suelen da Silva, Morais, Sibele Andrade, Roberto, Marcos Barros, Luiz, Livia Coelho de, Assis, Anna Carolina M, Marinho, Luiz Felipe Lemes de, Araujo, Rafael de Souza, Pontes, Rodrigo Guerino, Stabeli, Carla Freire Celedonio, Fernandes, Soraya Dos Santos, Pereira   +12 more
openaire   +2 more sources

Multivalent Display of Single-Domain Antibodies

2012
Antigen-binding fragments, such as single-domain antibodies (sdAbs), can now be readily isolated by in vitro technologies. Antibody fragment libraries derived from immune or nonimmune sources are presented in a molecular display format, typically phage display, and binders to individual antigens are selected from the libraries by a so-called panning ...
Zhang, J., MacKenzie, C.R.
openaire   +3 more sources

Production of Single-Domain Antibodies in Pichia pastoris

2022
Single-domain antibodies (sdAbs) are binders that consist of a single immunoglobulin domain. SdAbs have gained importance as therapeutics, diagnostic reagents, and research tools. Functional sdAbs are commonly produced in Escherichia coli, which is a simple and widely used host for production of recombinant proteins. However, there are drawbacks of the
Yusei, Matsuzaki, Kaho, Kajiwara, Wataru, Aoki, Mitsuyoshi, Ueda   +3 more
openaire   +2 more sources