Results 281 to 290 of about 737,167 (335)

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Hybrid Microdiscs for Magnetically Induced Non‐Cytotoxic Thermal Actuation and Programmable Biomolecule Delivery

Advanced Functional Materials, EarlyView.
Hybrid magnetic microdiscs with customizable size and composition are engineered through refined photolithography and LbL assembly. Embedded Fe3O4 nanoparticles enable localized, non‐cytotoxic heating, while protein cargos can be incorporated in tunable quantities.
Daniela Iglesias‐Rojas, Danny Villanueva, Jon Mentxaka‐Salgado, Nerea Lete, Ane Olazagoitia‐Garmendia, Eduardo Fernández, Iñaki Orue, Alfredo García‐Arribas, Maria Luisa Fdez‐Gubieda, Ainara Castellanos‐Rubio, Robert Morel, Bernard Dieny, Maite Insausti, Idoia Castellanos‐Rubio   +13 more
wiley   +1 more source

Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Willliamson DJ, Zaza C, Carlon-Andres I, Gentili A, Daly JL, Holmes H, Thrush JW, Starling T, Neil S, Owens R, Malim MH, Tynan C, Simoncelli S, Padilla-Parra S.   +13 more
europepmc   +1 more source

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. [PDF]

J Biol Chem
Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E.   +14 more
europepmc   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA). [PDF]

Infect Immun
Vance DJ, Basir S, Piazza CL, Willsey GG, Haque HME, Tremblay JM, Rudolph MJ, Muriuki B, Cavacini L, Weis DD, Shoemaker CB, Mantis NJ.   +11 more
europepmc   +1 more source

eLife Assessment: Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

Dominique Soldati‐Favre
openalex   +1 more source

Single-domain antibodies against SARS-CoV-2 RBD from a two-stage phage screening of universal and focused synthetic libraries. [PDF]

BMC Infect Dis
Chen F, Liu Z, Kang W, Jiang F, Yang X, Yin F, Zhou Z, Li Z.   +7 more
europepmc   +1 more source

Serum immunoglobulin or albumin binding single-domain antibodies that enable tailored half-life extension of biologics in multiple animal species. [PDF]

Front Immunol
Harmsen MM, Ackerschott B, de Smit H.
europepmc   +1 more source

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Single-domain antibodies applied as antiviral immunotherapeutics

Journal of Virological Methods, 2023
Viral infections have been the cause of high mortality rates throughout different periods in history. Over the last two decades, outbreaks caused by zoonotic diseases and transmitted by arboviruses have had a significant impact on human health. The emergence of viral infections in different parts of the world encourages the search for new inputs to ...
Nidiane Dantas Reis, Prado, Nairo, Brilhante-Da-Silva, Rosa Maria Oliveira, Sousa, Michelle Suelen da Silva, Morais, Sibele Andrade, Roberto, Marcos Barros, Luiz, Livia Coelho de, Assis, Anna Carolina M, Marinho, Luiz Felipe Lemes de, Araujo, Rafael de Souza, Pontes, Rodrigo Guerino, Stabeli, Carla Freire Celedonio, Fernandes, Soraya Dos Santos, Pereira   +12 more
openaire   +2 more sources