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2006
Classical antibodies are complex assemblies, difficult to produce in bacteria, and too bulky for many medical or research applications. Therefore, substantial efforts aimed at finding simpler miniaturised antibodies. Heavy-chain antibodies in camelids are a natural source of such mini-antibodies. Moreover, their antigen-binding domain (named Nanobody),
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Classical antibodies are complex assemblies, difficult to produce in bacteria, and too bulky for many medical or research applications. Therefore, substantial efforts aimed at finding simpler miniaturised antibodies. Heavy-chain antibodies in camelids are a natural source of such mini-antibodies. Moreover, their antigen-binding domain (named Nanobody),
openaire +1 more source
From Whole Monoclonal Antibodies to Single Domain Antibodies: Think Small
2012The development of therapeutic monoclonal antibodies over the last 35 years has led to the emergence of a new class of useful therapeutic molecules. These "first generation" antibodies have been obtained thanks to the conjugated and huge efforts of both academic and biotech researchers.
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Applications of single-cell RNA sequencing in drug discovery and development
Nature Reviews Drug Discovery, 2023Joon Sang Lee +2 more
exaly
The technological landscape and applications of single-cell multi-omics
Nature Reviews Molecular Cell Biology, 2023Zhiliang Bai, Rahul Satija, Rong Fan
exaly
Single Domain Antibodies - Methods and Protocols
2012The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined ...
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Exploring bacterial cell biology with single-molecule tracking and super-resolution imaging
Nature Reviews Microbiology, 2013Andreas Gahlmann
exaly