Results 71 to 80 of about 1,169,281 (338)

The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase [PDF]

, 2013
RbpA is a small non-DNA-binding transcription factor that associates with RNA polymerase holoenzyme and stimulates transcription in actinobacteria, including Streptomyces coelicolor and Mycobacterium tuberculosis.
Aline Tabib-Salazar, Alting-Mees, Babcock, Bergendahl, Bierman, Bing Liu, Bougdour, Bucca, Burgess, Buttner, Campbell, Campbell, Chakraburtty, Cornilescu, Dey, England, Feklistov, Fletcher, Fontán, Forti, Gaal, Gabriel, Gruber, Haugen, Herring, Hsu, Hu, Hu, Huang, Karimova, Karimova, Kathleen O’Dwyer, Kelemen, Kelley, Kieser, Kim, Krishna, Manganelli, Manganelli, Mantsyzov, Marchant, Marie-Laure Parsy, Mark S. Paget, McClellan, Monteil, Monteil, Murakami, Newell, Otani, O’Connor, Paget, Paget, Paget, Paget, Panina, Peter J. Simpson, Philip Doughty, Pratt, Raffaelle, Richard A. Lewis, Rieping, Saecker, Sattler, Schwartz, Selmer, Sivashanmugam, Somadri Ghosh, Steve J. Matthews, Studier, Studier, Typas, van Wezel, Vassylyev, Ventura, Viollier, Vockenhuber, Wang, WHO, Young, Zhang, Zhang, Zhuo, Österberg   +82 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation [PDF]

, 2009
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy.
Kadam, Snehalata, McMahon, Amy, Stathopoulos, Angelike, Tzou, Phoebe   +3 more
core   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Construction of Novel Bispecific Single-Domain Antibodies (BiSdAbs) with Potent Antiangiogenic Activities

Pharmaceutical Fronts, 2020
The development of bispecific antibodies (BsAbs) has had a profound impact on cancer immunotherapy. Single-domain antibodies (SdAbs) could offer advantages over other antibody formats for the generation of a BsAbs, such as small size (∼12–15 kDa), with ...
Xianglei Liu, Tianyuan Sun, Qiuhan Ge, Jianwei Zhu   +3 more
doaj   +1 more source

Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody

Journal of Biological Chemistry, 2020
Since their discovery, the matrix metalloproteinase (MMP) family proteases have been considered as therapeutic targets in numerous diseases and disorders.
Amir S. Razai, B. Eckelman, G. Salvesen
semanticscholar   +1 more source

Inhibitory antibodies designed for matrix metalloproteinase modulation [PDF]

, 2019
The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis.
Fischer, Thomas, Riedl, Rainer
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Progress of Single-domain Antibodies in Molecular Imaging of Tumors

Zhongliu Fangzhi Yanjiu, 2019
A single-domain antibody (sdAb) is the variable region extracted from antibodies with only heavy chains found in camelid serum. Single-domain antibodies have the characteristics of easy expression, good solubility, great stability and weak immunogenicity.
ZHANG Meixin, LIU Teli, GUO Xiaoyi, XU Xiaoxia, ZHU Hua, YANG Zhi   +5 more
doaj   +1 more source