Results 101 to 110 of about 12,854,075 (243)

Single-event upsets in photoreceivers for Multi-Gb/s SLHC data transmission

, 2011
A 63 MeV proton beam was used to perform a single event upset (SEU) test on a candidate component for a future high luminosity large hadron collider (HL-LHC) high speed optical.
Moreira, P., Stephane Detraz, Detraz, Stephane, Seif El Nasr-Storey, Sarah, Spyridon Papadopoulos, Pavel Stejskal, Sigaud, Christophe, Vasey, F., Stejskal, P., Vasey, Francois, Troska, J., Soos, Csaba, Menouni, M., Paulo Moreira, Jan Troska, Mohsine Menouni, Troska, Jan, Detraz, S., Sarah Seif El Nasr-Storey, Seif El Nasr-Storey, S., Papadopoulos, S., Menouni, Mohsine, Christophe Sigaud, Csaba Soos, Sigaud, C., Stejskal, Pavel, Gui, P., Gui, Ping, Ping Gui, Soos, C., Moreira, Paulo, Francois Vasey, Papadopoulos, Spyridon   +32 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Single-event transient analysis on radiation-hardened SiGe and GaN ringfet’s using 3D TCAD simulations

Discover Materials
The ringFET devices are investigated for radiation-hardened applications employing advanced semiconductor materials such as SiGe and GaN by conducting 3D TCAD simulations.
M. Ramya, K. K. Nagarajan, R. Binowesley, A. J. Bhuvaneshwari, P. Kaythry, K. J. Jegadish Kumar, R. Vinu, C. Parthasarathy, S. Gomathi   +8 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A single event transient hardening circuit design technique based on strengthening

, 2013
In a near future of high-density and low-power technologies, the study of soft errors will not only be relevant for memory systems and latches of logic circuits, but also for the combinational parts of logic circuits which seriously affect the system's ...
Amat Bertran, Esteve, Calomarde Palomino, Antonio, Moll Echeto, Francisco de Borja, Rubio Sola, Jose Antonio   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Waveform-Feature-Driven Diagnosis and Physics-Constrained Self-Correction of Representative EMT Component Implementation Faults: A Multi-Agent Feasibility Study

Sensors
Latent faults in electromagnetic transient (EMT) components can alter initialization, switching-event, and history-state semantics while producing sparse or small waveform discrepancies.
Jieran Zhang, Jie Zhang, Pan Wu, Jin Xu, Keyou Wang   +4 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source