Results 71 to 80 of about 421,332 (261)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

CONTACT AND ROTATION ANALYSIS OF SINGLE ROLLER ENVELOPING FACE WORM DRIVE

open access: yesJixie qiangdu, 2021
Based on the meshing theory of single roller enveloping end face worm drive,the distribution of contact line and the length of contact line on the cylindrical surface of the drive pair,and the self-rotation angle of the roller,and the self-rotation angle
LIAO HongHui   +3 more
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Suitability Analysis of Rice Cropping Patterns in China Using the MaxEnt Model

open access: yesAgronomy
Climate warming is reshaping hydrothermal resources for rice production, but the climatic responses of different rice-based cropping systems have not been sufficiently compared. This study evaluated the climatic suitability and dominant climatic controls
Yunyi Cai   +8 more
doaj   +1 more source

Single versus dual-rate learning when exposed to Coriolis forces during reaching movements.

open access: yesPLoS ONE, 2020
When we reach for an object during a passive whole body rotation, a tangential Coriolis force is generated on the arm. Yet, within a few trials, the brain adapts to this force so it does not disrupt the reach. Is this adaptation governed by a single-rate
Judith L Rudolph   +3 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

Single-Grasp Detection Based on Rotational Region CNN [PDF]

open access: yes, 2019
Object grasp detection is foundational to intelligent robotic manipulation. Different from typical object detection tasks, grasp detection tasks need to tackle the orientation of the graspable region in addition to localizing the region since the ground truth box of the grasp detection is arbitrary-oriented in the grasp datasets.
Jiang, Shan   +4 more
openaire   +2 more sources

Operational performance research of layered rotary tillage and ridging machine on for the sticky soil using DEM

open access: yesScientific Reports
To address the challenges of low soil fragmentation rates and high tillage resistance during land preparation for the sticky soil in southwest China, a double-shaft layered rotary tillage and ridging machine was designed to enhance the soil layer ...
Tao Zhang   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

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