Results 71 to 80 of about 404,024 (253)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Tracking single-particle rotation during macrophage uptake

Soft Matter, 2015
We investigated the rotational dynamics of single microparticles during their internalization by macrophage cells. The microparticles used were triblock patchy particles that display two fluorescent patches on their two poles. The optical anisotropy made
Lucero Sánchez, Paul Patton, Stephen M. Anthony, Yi Yi, Yan Yu   +4 more
semanticscholar   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Structural design and vibration characteristics of a contra-rotating drilling tool based on planetary gear trains

Frontiers in Mechanical Engineering
IntroductionTo reduce severe drill string vibration and improve drilling efficiency in deep drilling, which are often accompanied by significant energy loss.MethodThe contra- rotation of the inner and outer drill bits was facilitated by planetary gear ...
Li Qian, Liu Xuyong, Liu Huaiwei, Zhu Zhigang, Deng Hehong, Li Guangjun, Zhou Haina, Feng Xuming, Zeng Yuefei   +8 more
doaj   +1 more source

Research on the selection of rotation stopping block’s arrangement for single-type low-floor tram

机车电传动, 2022
Single-type low-floor trams have been widely used in the construction of urban light rail transit in recent years. As a common component of low-floor trams, the rotation stopping block can limit the relative swing angle range between the car body and the
XIE Yuchen, LIANG Shulin, CHI Maoru, CAI Wubin, WANG Huansheng, FAN Qingyu   +5 more
doaj  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

First Metatarsal Pronation, Distal metatarsal articular angle and sesamoid reduction after Modified scarf osteotomy with single screw fixation

Foot & Ankle Orthopaedics, 2018
Category: Bunion Introduction/Purpose: Scarf osteotomy is a very popular procedure to hallux valgus surgical correction. No literature reported the correction of rotation of first metatarsal after a Scarf osteotomy.
Chao Sun MD, Zhi Wang MD
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Adolescent differences in knee stability following computer-assisted anterior cruciate ligament reconstruction

Orthopedic Reviews, 2014
Anterior cruciate ligament (ACL) surgery is being increasingly performed in the adolescent population. Computer navigation offers a reliable way to quantitatively measure knee stability during ACL reconstruction.
Melissa A. Christino, Bryan G. Vopat, Gregory R. Waryasz, Alexander Mayer, Steven E. Reinert, Robert M. Shalvoy   +5 more
doaj   +1 more source