Results 91 to 100 of about 22,194 (282)

Computer Three-Dimensional Reconstruction of the Sinoatrial Node [PDF]

Circulation, 2005
Background— There is an effort to build an anatomically and biophysically detailed virtual heart, and, although there are models for the atria and ventricles, there is no model for the sinoatrial node (SAN).
Dobrzynski, H., Li, J., Tellez, J., Greener, I. D., Nikolski, V. P., Wright, S. E., Parson, S. H., Jones, S. A., Lancaster, M. K., Yamamoto, M., Honjo, H., Takagishi, Y., Kodama, I., Efimov, I. R., Billeter, R., Boyett, M. R.   +15 more
openaire   +2 more sources

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling [PDF]

, 2017
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system.
A Atkinson, B Schmitt, CM Ambrosi, CM Ambrosi, D Sánchez-Quintana, E VR de Castroviejo, F Davies, GV Chow, H Dobrzynski, H Dobrzynski, H Kurosawa, ID Greener, J Li, J Zhao, JC Hutchinson, JC Jarvis, KH Yiu, KHWJ Tusscher ten, M Loukas, M Smerup, M Smerup, MR Boyett, MR Boyett, N Chandler, N Piazza, N-Y Chan, NJ Chandler, NS Jeffery, O Aslanidi, OV Aslanidi, OV Aslanidi, PM Gignac, PW Oosthoek, RC Truex, RH Anderson, RH Anderson, RS Stephenson, RS Stephenson, S Dawkins, S Inada, S Yoo, T Nikolaidou, T-a Matsuyama, TA Csepe, TD Butters, VV Fedorov, VV Fedorov, WJ Hucker, Y Wang, Y-S Ko   +49 more
core   +1 more source

The cardiac pacemakers: A paradigm of robustness in evolutionary biology

The Journal of Physiology, EarlyView.
Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley   +1 more source

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Frontiers in Physiology, 2015
The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv, Kenta eTsutsui, Edward eLakatta   +2 more
doaj   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Demonstration of the Anatomical Tachycardia Circuit in Sinoatrial Node Reentrant Tachycardia: Analysis Using the Entrainment Method [PDF]

, 2020
Hiroshige Yamabe, Yoshiya Orita
openalex   +1 more source

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +1 more source

Modeling familial sinus node dysfunction with a large intergenic deletion between PITX2 and ANK2 using iPS cell-derived sinoatrial nodal-like cardiomyocytes [PDF]

, 2023
Takanori Aizawa, Takeru Makiyama, Hiroshige Murata, Takashi Takaki, Manon Baudic, Jingshan Gao, Tomoko Imamura, Seiko Ohno, Yoshinori Yoshida, Wataru Shimizu, Naomasa Makita, Julien Barc, Jean‐Jacques Schott, Minoru Horie, Takeshi Kimura   +14 more
openalex   +1 more source