Results 91 to 100 of about 1,311,541 (283)

The Calcium and Voltage Clocks in Sinoatrial Node Automaticity [PDF]

Korean Circulation Journal, 2009
Recent evidence indicates that the voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. Since the intact SAN is a heterogeneous structure that includes multiple different cell types interacting with each ...
Boyoung Joung, Shien-Fong Lin, Masahiro Ogawa, Peng Sheng Chen   +3 more
openaire   +4 more sources

Pathophysiological Significance of T-type Ca2+ Channels: Properties and Functional Roles of T-type Ca2+ Channels in Cardiac Pacemaking

Journal of Pharmacological Sciences, 2005
Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj  

Clinical Significance and Management of Atrioventricular Block Associated With Bradycardic/Antiarrhythmic Drug Therapy: Drug‐Induced or Drug‐Revealed?

Journal of Cardiovascular Electrophysiology, EarlyView.
Schematic representation of the management pathway in drug‐related advanced atrioventricular block. ABSTRACT The development of advanced atrioventricular block (AVB) in patients on bradycardic and/or antiarrhythmic therapy (drug‐related AVB) represents a clinical challenge, raising the question of whether the AVB is directly caused by these agents ...
Dimitrios Sfairopoulos, George Bazoukis, Skevos Sideris, Nikolaos Fragakis, Konstantinos Letsas, Konstantinos Zekios, Tong Liu, Panagiotis Korantzopoulos   +7 more
wiley   +1 more source

Acute Isolation of Cells from Murine Sino-atrial Node

Bio-Protocol, 2020
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN).
Qadeer Aziz, Muriel Nobles, Andrew Tinker   +2 more
doaj   +1 more source

Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. [PDF]

PLoS ONE, 2013
In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and ...
Alondra Albarado-Ibañez, José Everardo Avelino-Cruz, Myrian Velasco, Julián Torres-Jácome, Marcia Hiriart   +4 more
doaj   +1 more source

Surgical therapy for atrial tachycardia in adults [PDF]

, 1989
Eighteen adult patients with atrial tachycardia refractory to treatment with a mean of four drugs underwent attempted surgical cure. Atrial tachycardia originated in the right atrium in 17 patients and the left atrium in 1 patient.
Johnson, David C., McGuire, Mark A., Nunn, Graham R., Ross, David L., Uther, John B., Yung, Teresa   +5 more
core   +1 more source

TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling

Heart and Vessels, 2018
Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS). Transient receptor potential (TRP) subfamily M member 7 (TRPM7) is implicated in cardiac fibrosis. However, the mechanisms underlying the regulation of sinoatrial node
Hongbin Zhong, Tingjun Wang, Guili Lian, Changsheng Xu, Huajun Wang, Liang-di Xie   +5 more
semanticscholar   +1 more source

Disorders of gut–brain interaction through the lens of polyvagal theory

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
This paper introduces a metric, vagal efficiency (VE), that tracks a brainstem “switching” mechanism regulating blood pressure's effect on vagal control of the heart and gut. Potentially offering insights into gut–brain interaction disorders. Abstract This paper introduces a metric capable of tracking a hypothetical brainstem “switching” mechanism ...
Stephen W. Porges
wiley   +1 more source

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Thomas A. Csepe, Jichao Zhao, Brian J. Hansen, Ning Li, Lidiya V. Sul, Praise Lim, Yufeng Wang, Orlando P. Simonetti, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Vadim V. Fedorov   +11 more
openaire   +4 more sources

The Relationship between Intracardiac Atrial Sensing Values and Atrial High-rate Episodes in Patients With Permanent Pacemakers Implanted due to Sick Sinus Syndrome

Haseki Tıp Bülteni, 2022
Aim:An increase in fibrosis and collagen in the atrium and sinus node tissues constitutes the basic pathophysiology of sick sinus syndrome (SSS). We aimed to investigate the relationship between P-wave sensing values and atrial high rate episodes (AHRE ...
Sukru Arslan, Betul Balaban Kocas, Omer Dogan, Selim Tanyolac, Isil Uzunhasan   +4 more
doaj   +1 more source