Results 71 to 80 of about 10,333 (179)

Is sodium current present in human sinoatrial node cells?

International Journal of Biological Sciences, 2009
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa) plays a role in the pacemaker activity of the human ...
Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
doaj  

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Thomas A. Csepe, Jichao Zhao, Brian J. Hansen, Ning Li, Lidiya V. Sul, Praise Lim, Yufeng Wang, Orlando P. Simonetti, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Vadim V. Fedorov   +11 more
openaire   +3 more sources

On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Group III/IV leg muscle afferent feedback has previously been recognized as an important determinant of the cardiovascular response to exercise lasting <5 min. Here we demonstrate that the activity of these neurons is crucial in regulating central and peripheral haemodynamic responses during steady state exercise of longer ...
D. Iannetta, F. G. Laginestra, T. S. Thurston, R. H. Jenkinson, J. Chang, H.‐Y. Wan, R. M. Broxterman, J. C. Weavil, M. Amann   +8 more
wiley   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 8, August 2026.
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande, Valeria Krzhizhanovskaya, Lex M. van Loon, Nathalie van der Velde, Eveline P. van Poelgeest, Marjolein Klop, Jurgen A. H. R. Claassen, Alfons G. Hoekstra   +7 more
wiley   +1 more source

Comparative Efficacy and Safety of Ivabradine vs. Beta Blockers in Heart Transplant Patients: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Elevated resting heart rate in heart transplant (HTx) recipients due to graft denervation is associated with adverse outcomes. Ivabradine and beta blockers are commonly used for heart rate control post‐HTx, but their comparative effectiveness and safety remain unclear.
Ahmad Hassan, Maaz Amir, Mehrab Naeem, Eshah Fatima Ali, Ubaid Ullah, Muhammad Asad Jahangir, Muhammad Umer Hassaan, Rafia Aman, Hafiza Rafia Rifat, Mohammad Faez Nazir, Muhammad Numan Awais, Areeba Alizai, Sidra Gul, Adeena Asif   +13 more
wiley   +1 more source

Acute Isolation of Cells from Murine Sino-atrial Node

Bio-Protocol, 2020
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN).
Qadeer Aziz, Muriel Nobles, Andrew Tinker   +2 more
doaj   +1 more source

Atrial High‐Rate Episodes Mirror Atrial Fibrillation in Stroke Prediction: Evidence From an Indian Prospective Cohort

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
This prospective matched cohort study, which generates hypotheses, finds that device‐detected AF lasting under 24 h is linked to a notably increased risk of stroke/TIA and progression to clinical AF among Indian patients. ABSTRACT Aims To assess the risk of stroke/TIA and progression to atrial fibrillation (AF) in Indian patients with device‐detected ...
Sedhupathi Shanmugam, Sreevilasam P. Abhilash, Jyothi Vijay, Sapna erat Sreedharan, Narayanan Namboodiri   +4 more
wiley   +1 more source

sinoatrial node

Citation: 'sinoatrial node' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11220 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Stokes–Adams Syncope and Ventricular Standstill

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Stokes–Adams syncope has various etiologies including atrioventricular conduction delays, ischemia, or vagal mechanisms. Careful EKG analysis including serial EKGs, may help identify contributory mechanisms to the etiology of syncope, even after permanent pacemaker implantation.
Khalid Shakfeh, Takumi Yamada, Aditya Saini   +2 more
wiley   +1 more source