Results 71 to 80 of about 12,234 (213)

Computer Three-Dimensional Reconstruction of the Sinoatrial Node [PDF]

Circulation, 2005
Background— There is an effort to build an anatomically and biophysically detailed virtual heart, and, although there are models for the atria and ventricles, there is no model for the sinoatrial node (SAN).
Dobrzynski, H.; id_orcid 0000-0003-4754-5975, Li, J., Tellez, J., Greener, I. D., Nikolski, V. P., Wright, S. E., Parson, S. H., Jones, S. A., Lancaster, M. K., Yamamoto, M., Honjo, H., Takagishi, Y., Kodama, I., Efimov, I. R., Billeter, R., Boyett, M. R.   +15 more
openaire   +2 more sources

The morphologic development of the sinoatrial node in the mouse

The American Journal of Cardiology, 1970
Abstract A plastic embedding technique was employed on mouse embryos after fixation with a gluteraldehyde-paraformaldehyde mixture and preparation of large, 1 to 2 μ sections cut on a rotary microtome with steel knives. It was then possible to trace the sinoatrial node back to mouse embryos of 4 sol1 2 mm crown-rump length ( 10 1 2 days
Departments of Pediatrics (Cardiology) and Pathology, University of Florida College of Medicine, Gainesville, Fla. 32601 USA ( host institution ), Van Mierop, L.H.S., Gessner, Ira H.   +2 more
openaire   +3 more sources

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Acute Isolation of Cells from Murine Sino-atrial Node

Bio-Protocol, 2020
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN).
Qadeer Aziz, Muriel Nobles, Andrew Tinker   +2 more
doaj   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Aging and Sinoatrial Node Dysfunction [PDF]

Circulation, 2007
In the century since the discovery by Keith and Flack of the sinoatrial node in the mole heart, a detailed mosaic of its cellular, anatomic, and electrophysiological properties has emerged. The human sinus node has been found to be anatomically constant and well localized, occupying an approximately 10-mm subepicardial region on the sulcus terminalis ...
Haris M. Haqqani, Jonathan M. Kalman
openaire   +1 more source

Coupling between two Resonant model sinoatrial node cells.

, 2019
A: Parameters of the action potential of sinoatrial node cell. MDP is a maximal diastolic potential, Vmax is the maximum potential, and VTh is the threshold potential. B: State controller of the Resonant model of a sinoatrial node cell.
Partha S. Roop (6725684), Nitish D. Patel (6725678), Avinash Malik (6725681), Sucheta Sehgal (6725675), Mark L. Trew (6725687)   +4 more
core   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source