Results 61 to 70 of about 10,333 (179)

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

Nature Communications, 2021
The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit ...
Dandan Liang, Jinfeng Xue, Li Geng, Liping Zhou, Bo Lv, Qiao Zeng, Ke Xiong, Huixing Zhou, Duanyang Xie, Fulei Zhang, Jie Liu, Yi Liu, Li Li, Jian Yang, Zhigang Xue, Yi-Han Chen   +15 more
doaj   +1 more source

The morphologic development of the sinoatrial node in the mouse

The American Journal of Cardiology, 1970
Abstract A plastic embedding technique was employed on mouse embryos after fixation with a gluteraldehyde-paraformaldehyde mixture and preparation of large, 1 to 2 μ sections cut on a rotary microtome with steel knives. It was then possible to trace the sinoatrial node back to mouse embryos of 4 sol1 2 mm crown-rump length ( 10 1 2 days
Departments of Pediatrics (Cardiology) and Pathology, University of Florida College of Medicine, Gainesville, Fla. 32601 USA ( host institution ), Van Mierop, L.H.S., Gessner, Ira H.   +2 more
openaire   +3 more sources

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

A case report of sinoatrial arrest caused by temporal lobe epilepsy in subclinical glioblastoma

BMC Cardiovascular Disorders, 2020
Background Atrial fibrillation with symptomatic bradycardia, higher grade atrioventricular block, and sinus node disease are all common indications for permanent pacemaker implantation.
Jörg Reifart, Marlene Tschernatsch, Christian W. Hamm, Johannes Sperzel, Andreas Hain   +4 more
doaj   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source