Results 41 to 50 of about 12,234 (213)
Local tissue mechanics control cardiac pacemaker cell embryonic patterning
Life Science Alliance, 2023 Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function. Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart.
Trevor Henley +5 more
doaj +1 more source
Analisis Numerik Model Sinoatrial Node menggunakan Metode Euler [PDF]
, 2020 The synoatrial node is an important part of the human heart, which functions as a regulator and generator of the frequency of the electrical signals that produce the heart rate.
Maulidiyah, Jauharoh
core
Function and Dysfunction of Human Sinoatrial Node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release). Using optical mapping in Langendorff-perfused canine right atrium, we previously demonstrated that the β-adrenergic stimulation pushes the ...
Joung, Boyoung, Chen, Peng-Sheng
openaire +3 more sources
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
The sophisticated architecture of the rat atrioventricular node [PDF]
, 2005 In the mammalian heart, the action potential spontaneously generated in the sinoatrial (SA) node propagates through the atria to reach the atrioventricular (AV) node.
Yoo, Shin
core
Regenerative Therapy, 2022 Introduction: Dysfunction of the sinoatrial node (SAN) cells causes arrhythmias, and many patients require artificial cardiac pacemaker implantation. However, the mechanism of impaired SAN automaticity remains unknown, and the generation of human SAN ...
Takayuki Wakimizu +9 more
doaj +1 more source
Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models
Pediatric Discovery, EarlyView.ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou +3 more
wiley +1 more source
PLoS ONE, 2014 The aim of the study was to develop a three-dimensional (3D) anatomically-detailed model of the rabbit right atrium containing the sinoatrial and atrioventricular nodes to study the electrophysiology of the nodes. A model was generated based on 3D images
Jue Li +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node ...
Kentaro Takeda +4 more
doaj +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT In patients with atrial fibrillation (AF), sinus node disease (SND) represents a potentially reversible concomitant condition. Initial treatment with catheter ablation (CA) aimed at restoration of sinus rhythm may provide an alternative to pacemaker implantation. In this case series, 15 elderly patients (>65 years) with AF and SND underwent CA,
Cerine Benachi +9 more
wiley +1 more source