Cell-based Biological Pacemakers: Progress and Problems [PDF]
, 2018 The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases.
Ito, Hiroshi +2 more
core +1 more source
SCN5A and sinoatrial node pacemaker function [PDF]
Cardiovascular Research, 2007 The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells.
Lei, Ming +3 more
openaire +2 more sources
Local tissue mechanics control cardiac pacemaker cell embryonic patterning
Life Science Alliance, 2023 Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function. Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart.
Trevor Henley +5 more
doaj +1 more source
Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. [PDF]
, 2013 The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), depolarization by cardiac Na-Ca ...
Alber, Sarah +13 more
core +2 more sources
Regenerative Therapy, 2022 Introduction: Dysfunction of the sinoatrial node (SAN) cells causes arrhythmias, and many patients require artificial cardiac pacemaker implantation. However, the mechanism of impaired SAN automaticity remains unknown, and the generation of human SAN ...
Takayuki Wakimizu +9 more
doaj +1 more source
The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]
, 2012 Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core +1 more source
Application of novel Modified Biological Aerated Filter (MBAF) as a promising post-treatment for water reuse: Modification in configuration and backwashing process [PDF]
, 2017 Biological Aerated Filter (BAF) reactors due to their plentiful biomass, high shockability, high efficiency, good filtration, availability and lack of need for large land areas, are enjoying from great importance in advanced wastewater treatment ...
Ebrahimi, A. A. +6 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation [PDF]
, 2013 Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K+ current (IKACh) in the control of SAN pacemaking and heart rate is not ...
Audoubert, Matthieu +14 more
core +3 more sources
Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models
Pediatric Discovery, EarlyView.ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou +3 more
wiley +1 more source