Results 31 to 40 of about 12,234 (213)
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
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Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
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The sinoatrial node, a heterogeneous pacemaker structure [PDF]
Cardiovascular Research, 2000 This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing.
M R, Boyett, H, Honjo, I, Kodama
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Pathophysiology of Cav1.3 L-type calcium channels in the heart
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
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Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node
Revista Facultad de Ingeniería Universidad de Antioquia, 2013 A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett.
Daniel Alfonso Sierra +2 more
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Nature Communications, 2020 The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their ...
Ning Li +20 more
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Histopathological changes in the electrical conduction of cardiac nodes after acute myocardial infarction in dogs and horses, compared with findings in humans: A histological, morphometrical, and immunohistochemical study [PDF]
Veterinary World, 2023 Background and Aim: The heart conduction system is responsible for the occurrence of various types of cardiac arrhythmia. This study aimed to histologically and morphometrically describe damaged cardiac nodes during acute myocardial infarction and to ...
Fabián Gómez-Torres +2 more
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Do human sinoatrial node cells have t-tubules?
Translational Research in Anatomy, 2021 Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca2+ clocks, regulated by strictly ...
Maria A. Petkova, Halina Dobrzynski
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Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node
, 2002 2002-12Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^ release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of ...
MITSUI, Kazuyuki +7 more
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Catheter ablation of sinoatrial node reentrant tachycardia
, 1994 Objectives. This study evaluates 1) the safety and efficacy of catheter delivery of radiofrequency current to eliminate sustained sinoatrial node reentrant tachycardia; 2) the incident of sinoatrial node reentrant tachycardia in the current group of ...
Greenfield, Ruth Ann +5 more
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