Results 31 to 40 of about 455,752 (196)

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +1 more source

Pathophysiology of Cav1.3 L-type calcium channels in the heart

Frontiers in Physiology, 2023
Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri, Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Yongxia Sarah Qu, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Chahine, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +10 more
doaj   +1 more source

The sinoatrial node, a heterogeneous pacemaker structure [PDF]

Cardiovascular Research, 2000
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing.
M R, Boyett, H, Honjo, I, Kodama
openaire   +2 more sources

Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node

Revista Facultad de Ingeniería Universidad de Antioquia, 2013
A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett.
Daniel Alfonso Sierra, Oscar Leonel Rueda, Carlos Rodrigo Correa   +2 more
doaj   +1 more source

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Nature Communications, 2020
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their ...
Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul ML. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov   +20 more
doaj   +1 more source

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF. [PDF]

JACC Clin Electrophysiol
Microvascular rarefaction is a feature of heart failure with preserved ejection fraction (HFpEF) that may underlie associated rhythm disturbances. Angiotensin II (AngII) signaling has been implicated, but its role in sinoatrial (SA) node dysfunction remains unclear.The authors tested whether changes in SA node microvascular architecture contribute to ...
Manning D, Rivera EJ, Rhana P, Matsumoto C, Fong Z, Thai PN, Muñoz MF, Contreras JE, Kim S, Grainger N, Chiamvimonvat N, Bautista GM, Santana LF.   +12 more
europepmc   +4 more sources

Catheter ablation of sinoatrial node reentrant tachycardia [PDF]

, 1994
Objectives. This study evaluates 1) the safety and efficacy of catheter delivery of radiofrequency current to eliminate sustained sinoatrial node reentrant tachycardia; 2) the incident of sinoatrial node reentrant tachycardia in the current group of ...
Greenfield, Ruth Ann, Sanders, William E., Shenasa, Hossein, Sorrentino, Robert A., Hamer, Mark E., Wharton, J.Marcus   +5 more
core   +1 more source

Histopathological changes in the electrical conduction of cardiac nodes after acute myocardial infarction in dogs and horses, compared with findings in humans: A histological, morphometrical, and immunohistochemical study [PDF]

Veterinary World, 2023
Background and Aim: The heart conduction system is responsible for the occurrence of various types of cardiac arrhythmia. This study aimed to histologically and morphometrically describe damaged cardiac nodes during acute myocardial infarction and to ...
Fabián Gómez-Torres, Luis Ballesteros-Acuña, Amparo Ruíz-Sauri   +2 more
doaj   +1 more source

Do human sinoatrial node cells have t-tubules?

Translational Research in Anatomy, 2021
Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca2+ clocks, regulated by strictly ...
Maria A. Petkova, Halina Dobrzynski
doaj   +1 more source

Local tissue mechanics control cardiac pacemaker cell embryonic patterning

Life Science Alliance, 2023
Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function. Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart.
Trevor Henley, Julie Goudy, Marietta Easterling, Carrie Donley, Robert Wirka, Michael Bressan   +5 more
doaj   +1 more source