Results 31 to 40 of about 10,333 (179)
Brazilian Journal of Anesthesiology, 2022 Background: Dexmedetomidine (Dex) is widely used, and its most common side effect is bradycardia. The complete mechanism through which Dex induces bradycardia has not been elucidated.
Yong-Qiang Yin +3 more
doaj +1 more source
Telocytes in the human sinoatrial node [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractThe sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile ...
Lubov B. Mitrofanova +3 more
openaire +2 more sources
Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
doaj +1 more source
Lithium-Induced Sinoatrial Node Dysfunction [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi, Ashish +3 more
openaire +2 more sources
Computer Modelling of the Sinoatrial Node [PDF]
Medical & Biological Engineering & Computing, 2006 Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
openaire +4 more sources
Journal of Pharmacological Sciences, 2005 Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj +1 more source
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +1 more source
Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
doaj +1 more source
Pathophysiology of Cav1.3 L-type calcium channels in the heart
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
doaj +1 more source
The sinoatrial node, a heterogeneous pacemaker structure [PDF]
Cardiovascular Research, 2000 This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing.
M R, Boyett, H, Honjo, I, Kodama
openaire +2 more sources