Results 11 to 20 of about 12,234 (213)
Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +16 more
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Translational Anatomy of the Sinoatrial Node [PDF]
JACC: Case ReportsAlejandro Jiménez Restrepo, MD +3 more
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SCN5A and sinoatrial node pacemaker function [PDF]
Cardiovascular Research, 2007 The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells.
Lei, Ming +3 more
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Is sodium current present in human sinoatrial node cells? [PDF]
International Journal of Biological Sciences, 2009 Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa) plays a role in the pacemaker activity of the human ...
Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
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Gap junctions in the rabbit sinoatrial node [PDF]
American Journal of Physiology-Heart and Circulatory Physiology, 2001 In comparison to the cellular basis of pacemaking, the electrical interactions mediating synchronization and conduction in the sinoatrial node are poorly understood. Therefore, we have taken a combined immunohistochemical and electrophysiological approach to characterize gap junctions in the nodal area.
S, Verheule +4 more
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CaMKII in sinoatrial node physiology and dysfunction
Frontiers in Pharmacology, 2014 The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu +2 more
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The pacemaker cell of the sinoatrial node of the rabbit
American Journal of Physiology-Heart and Circulatory Physiology, 1978 Rabbit sinoatrial nodes were isolated and studied in an attempt to determine the cell of origin of the true pacemaker potential. Cells of the sinoatrial node of the rabbit giving rise to the characteristic true pacemaker potential were iontophoretically tagged with lanthanum.
J J, Taylor, L S, D'Agrosa, E M, Burns
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Parasympathetic postganglionic pathways to the sinoatrial node
American Journal of Physiology-Heart and Circulatory Physiology, 1990 Vagal ganglia that innervate the canine sinoatrial node (SAN) have been localized to a fat pad overlying and surrounding the right pulmonary vein complex (PVFP). The ventral epicardial surface of the right atrium was mapped in seven dogs anesthetized with alpha-chloralose after beta-blockade (timolol) and cardiac sympathetic and parasympathetic ...
K M, Bluemel +4 more
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Possible sinoatrial node dysfunction in a 6-month-old domestic shorthair cat. [PDF]
JFMS Open RepCase summary A six-month-old male entire domestic shorthair cat was presented to the ophthalmology department for nasolacrimal duct cannulation and flushing, and castration under general anaesthesia.
Hillen F, Locquet L.
europepmc +2 more sources
Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]
PLoS ONE, 2017 Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck +8 more
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