Results 21 to 30 of about 20,476 (227)
Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
doaj +1 more source
Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]
, 2011 We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S. +3 more
core +3 more sources
Lithium-Induced Sinoatrial Node Dysfunction [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi, Ashish +3 more
openaire +2 more sources
The mind body problem, part three: ascension of sexual function to cerebral level [PDF]
, 2016 Physiologically, the somatic nervous system intervenes in external interaction between the body and environment, while autonomic nervous system ensures the functioning of internal organs.
Motofei, Ion G., Rowland, David L.
core +3 more sources
Effects of Cardiac Structural Remodelling During Heart Failure on Cardiac Excitation – Insights from a Heterogeneous 3D Model of the Rabbit Atria [PDF]
, 2015 Heart failure is a leading cause of morbidity and mortality in the western world. One of the effects of heart failure is the structural remodelling of cardiac tissue, including tissue dilation and development of fibrosis.
Boyett, Mark +7 more
core +2 more sources
Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF. [PDF]
JACC Clin ElectrophysiolManning D +12 more
europepmc +2 more sources
Computer Modelling of the Sinoatrial Node [PDF]
Medical & Biological Engineering & Computing, 2006 Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
openaire +4 more sources
Journal of Pharmacological Sciences, 2005 Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj +1 more source
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +1 more source
The effect of gag reflex on cardiac sympatovagal tone [PDF]
, 2012 Objectives: Heart velocity may be influenced by gagging. The medulla oblongata receives the afferents of gag reflex. Neuronal pools of vomiting, salivation and cardiac parasympathetic fibers are very close in this area.
Jamshir, M. +2 more
core +2 more sources