Results 51 to 60 of about 12,234 (213)
One-dimensional rabbit sinoatrial node models: benefits and limitations
, 2003 INTRODUCTION: Cardiac multicellular modeling has traditionally focused on ventricular electromechanics. More recently, models of the atria have started to emerge, and there is much interest in addressing sinoatrial node structure and function.
Garny, A +5 more
core +1 more source
In Silico Characterization of the Sinoatrial Node (v2.0)
, 2022 In silico experiments to study the sinoatrial node characteristics. The experiment script is able to modify several electrophysiological parameters using as an input a vtk ...
Axel Loewe +2 more
core +1 more source
Werner Irnich: Pioneer in the Development of the Dual‐Chamber Pacemaker—An Obituary
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Fifty years ago, Werner Irnich presented the concept of an optimal pacemaker capable of responding appropriately to various cardiac arrhythmias and perceptual disturbances, and intended to be used in 85% of patients. With this concept, Irnich was far ahead of his time. His proposed circuitry for AV block and atrial fibrillation, as well as his
Bernd Lemke
wiley +1 more source
In Silico Characterization of the Sinoatrial Node (v1.0)
, 2022 In silico experiments to study the sinoatrial node characteristics. The experiment script is able to modify several electrophysiological parameters using as an input a vtk ...
Sanchez, Jorge +2 more
core +1 more source
Mathematical Models of Cardiac Pacemaking Function
Frontiers in Physics, 2013 Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling;
Pan eLi +3 more
doaj +1 more source
Cerebrovascular regulation during heat stress
Experimental Physiology, EarlyView.Abstract Given that the brain is a highly metabolic organ and is enclosed by the skull, effective regulation of cerebral blood flow (CBF), not only for oxygen and nutrients supply but also as a means of convective heat exchange, is critical for preventing excessive elevations in brain temperature.
Kanoko Ito, Manabu Shibasaki
wiley +1 more source
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]
PeerJ, 2017 Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj +2 more sources
Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity
Frontiers in Cardiovascular Medicine, 2021 The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner +6 more
doaj +1 more source
The isolated working guinea pig heart: A functional and electrophysiological characterisation
Experimental Physiology, EarlyView.Abstract Small animal isolated perfused hearts have been used for over 150 years for the study of cardiac physiology and pharmacology. The guinea pig heart represents the smallest mammalian heart that replicates key features of the human heart – for example, with respect to cardiac action potential duration, ion channel expression, excitation ...
Grace C. Anderson‐Barker +1 more
wiley +1 more source
The cardiac pacemakers: A paradigm of robustness in evolutionary biology
The Journal of Physiology, EarlyView.Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley +1 more source