Results 91 to 100 of about 455,752 (196)

Rhythm Generating Mechanisms in Rat Sinoatrial Node

Current Medical Issues
Background: The major membrane currents responsible for sinoatrial (SA) rhythm generation are generally studied in isolated cardiac cells using electrophysiological tools. Such studies are resource and labor-intensive.
Jesi Charles, Latha Nedumaran, Swetha Raman, Elizabeth Vinod, Rajalakshmi Rajasegaran, Kamalakannan Vadivel, Anand Bhaskar, Sathya Subramani   +7 more
doaj   +1 more source

Transcriptional profile of the rat cardiovascular system at single-cell resolution

Cell Reports
Summary: We sought to characterize cellular composition across the cardiovascular system of the healthy Wistar rat, an important model in preclinical cardiovascular research.
Alessandro Arduini, Stephen J. Fleming, Ling Xiao, Amelia W. Hall, Amer-Denis Akkad, Mark D. Chaffin, Kayla J. Bendinelli, Nathan R. Tucker, Irinna Papangeli, Helene Mantineo, Patricio Flores-Bringas, Mehrtash Babadi, Christian M. Stegmann, Guillermo García-Cardeña, Mark E. Lindsay, Carla Klattenhoff, Patrick T. Ellinor   +16 more
doaj   +1 more source

Immunocytochemical Demonstration of the Equilibrative Nucleoside Transporter rENT1 in Rat Sinoatrial Node

, 2002
Adenosine exerts multiple receptor-mediated effects in the heart, including a negative chronotropic effect on the sinoatrial node. The aim of this study was to investigate the distribution of the equilibrative nucleoside transporter rENT1 in rat ...
C.E. Cass, M.R. Boyett, H. Musa, S.A. Baldwin, H. Dobrzynski, F. Abidi, J.D. Young, Z. Berry   +7 more
core   +1 more source

Rare Case of Rapidly Worsening REM Sleep Induced Bradycardia

Case Reports in Cardiology, 2015
Sinoatrial arrest also known as sinus pause occurs when sinoatrial node of the heart transiently ceases to generate the electrical impulse necessary for the myocardium to contract. It may last from 2.0 seconds to several minutes. Etiologies of sinoatrial
Ayyappa S. Duba, Suneetha Jasty, Ankit Mahajan, Vijay Kodadhala, Raza Khan, Prithviraj Rai, Mohammad Ghazvini   +6 more
doaj   +1 more source

Human sinoatrial node detailed electrophysiology model and human sinoatrial node Resonant model responses to perturbation in an ion transport pathway.

, 2019
A: Action potential waveforms simulated in human sinoatrial node cell electrophysiology model. B: Action potential waveforms simulated in human sinoatrial resonant model under control conditions (CTRL) (dark black solid line) and upon 10% (dotted line ...
Partha S. Roop (6725684), Nitish D. Patel (6725678), Avinash Malik (6725681), Sucheta Sehgal (6725675), Mark L. Trew (6725687)   +4 more
core   +1 more source

Simplified 2D Bidomain Model of Whole Heart Electrical Activity and ECG Generation

Measurement Science Review, 2014
The aim of this study was the development of a geometrically simple and highly computationally-efficient two dimensional (2D) biophysical model of whole heart electrical activity, incorporating spontaneous activation of the sinoatrial node (SAN), the ...
Sovilj Siniša, Magjarević Ratko, Abed Amr Al, Lovell Nigel H., Dokos Socrates   +4 more
doaj   +1 more source

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

, 2007
The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction, thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in heart function, the mechanisms that underlie its specification and
Wong, L. Y. Elaine, Christoffels, Vincent M., V. Wakker, D. E. Clout, Barnett, Phil, Hoogaars, Willem M. H., Ravesloot, Jan Hindrik, Clout, Danielle E., L.Y. E. Wong, Moorman, Antoon F. M., W. M.H. Hoogaars, Verkerk, Arie O., Engel, Angela, A. O. Verkerk, M. L. Bakker, P. Barnett, V. M. Christoffels, Verheijck, E. Etienne, Wakker, Vincent, E. E. Verheijck, A. F.M. Moorman, de Lange, Frederik J., A. Engel, Brons, Janynke F., J. F. Brons, Bakker, Martijn L., J. H. Ravesloot, F. J. de Lange   +27 more
core   +1 more source

Irrigación del nodo sinoatrial en población colombiana [PDF]

, 2011
Antecedentes: El conocimiento exacto de la integración anatomofisiológica del sistema de conducción del corazón, es fundamental para la comprensión fisiopatológica, el diagnóstico y el manejo de muchas de las complicaciones de la enfermedad coronaria y ...
Quijano Blanco, Yobany
core  

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

, 2019
The rate of contraction of the heart relies on proper development and function of the sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3+ pacemaker cells. Here, we have isolated and characterized the Tbx3+ cells from
Boukens, Bas J., Christoffels, Vincent M., Eif, Vincent W. W.,, Bakker, Martijn, Wakker, Vincent, Zaffran, Stéphane, de Gier-de Vries, Corrie, Duijvenboden, Karel, Van, Gier-de Vries, Corrie,, Gier-de Vries, Corrie, De, Stefanovic, Sonia, van Duijvenboden, Karel, Duijvenboden, Karel,, van Eif, Vincent W. W., Eif, Vincent W. W., Van, Verkerk, Arie O.   +15 more
core   +1 more source

Sustained inward current and pacemaker activity of mammalian sinoatrial node

, 2002
Introduction: A novel sustained inward Na+ current ist, which sensitive to Ca2+-antagonists and potentiated by beta-adrenergic stimulation, has been described in pacemaker cells of rabbit, guinea pig, and rat sinoatrial node, as well as rabbit AV node ...
Zhang, Henggui, Holden, Arun V., Boyett, Mark R.   +2 more
core   +1 more source