Results 101 to 110 of about 1,321,275 (276)

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Cardiomyopathy With Preexcitation and Conduction Abnormalities in a Child

Journal of Arrhythmia, Volume 41, Issue 5, October 2025.
An 11‐year‐old boy presented with dilated cardiomyopathy in association with a fasciculoventricular pathway and sinus node and atrioventricular conduction abnormalities. Whole exome sequencing revealed a novel variant of uncertain significance in LIM domain‐binding protein 3 (LDB3) which has not been heretofore described.
Gorav Sharma, Ansh Goswami, Siddharthan Deepti, Neeraj Parakh, Sudheer Kumar Arava   +4 more
wiley   +1 more source

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background Two‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A Smith, Jedidiah S. Snyder, V. Fedorov, V. Coppola, M. Anderson, P. Mohler, T. Hund   +13 more
semanticscholar   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix

PLoS ONE, 2017
Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
J. Gluck, Anthony W. Herren, Sergey Yechikov, Hillary K J Kao, Ambereen Khan, B. Phinney, N. Chiamvimonvat, J. Chan, D. Lieu   +8 more
semanticscholar   +1 more source

Phase response characteristics of sinoatrial node cells

Computers in Biology and Medicine, 2007
In this work, the dynamic response of the sinoatrial node (SAN), the natural pacemaker of the heart, to short external stimuli is investigated using the Zhang et al. model. The model equations are solved twice for the central cell and for the peripheral cell.
Tsalikakis, D. G., Zhang, H. G., Fotiadis, D. I., Kremmydas, G. P., Michalis, L. K.   +4 more
openaire   +4 more sources

Prevalence of Bundle Branch Block and Axis Deviation in Permanent Atrial Fibrillation and Gender Differences

Annals of Noninvasive Electrocardiology, Volume 30, Issue 5, September 2025.
Graphical abstract illustrating the relationship between bundle branch block (BBB) patterns, axis deviation, and atrial fibrillation (AF) in a retrospective study. The left panel depicts the study design those with atrial fibrillation, and the control group, while the middle and right panel highlights the results and QRS axis deviation on a schematic ...
Raymond Farah, Mor Kdoshim, Rola Khamisy‐Farah   +2 more
wiley   +1 more source

Cardiovascular autonomic dysfunction precedes cardiovascular disease and all‐cause mortality: 11‐year follow‐up in the ADDITION‐PRO study

Diabetes, Obesity and Metabolism, Volume 27, Issue 9, Page 5147-5159, September 2025.
Abstract Aim We aim to determine the impact of multiday heart rate variability (HRV) on the risk of major adverse cardiovascular events (MACE), heart failure and mortality in people at high risk of diabetes. Materials and Methods Multiday HRV and mean heart rate (mHR) were measured in 1627 participants from the ADDITION‐PRO study between 2009 and 2011.
Jonas R. Schaarup, Lasse Bjerg, Christian S. Hansen, Erik L. Grove, Signe T. Andersen, Dorte Vistisen, Søren Brage, Annelli Sandbæk, Daniel R. Witte   +8 more
wiley   +1 more source

Electrical activity of sinoatrial node cells of the rabbit surviving a long exposure to cold Tyrode's solution. [PDF]

, 1977
Kosuke Nishi, Y Yoshikawa, Fumio Takenaka, Norio Akaike   +3 more
openalex   +1 more source