Results 101 to 110 of about 1,344,270 (316)
Development, 2019 The sinoatrial node (SAN), the primary cardiac pacemaker, consists of a head domain and a junction/tail domain that exhibit different functional properties. However, the underlying molecular mechanism defining these two pacemaker domains remains elusive.
Hua Li +11 more
semanticscholar +1 more source
The Evolution of Sinoatrial Node Function in Man [PDF]
, 1973 The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Bigger, J. Thomas, Strauss, Harold C.
core +1 more source
Molecular Pathway for the Localized Formation of the Sinoatrial Node [PDF]
Circulation Research, 2007 The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined.
Mommersteeg, M +10 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Computer Three-Dimensional Reconstruction of the Sinoatrial Node [PDF]
Circulation, 2005 Background— There is an effort to build an anatomically and biophysically detailed virtual heart, and, although there are models for the atria and ventricles, there is no model for the sinoatrial node (SAN).
Dobrzynski, H. +15 more
openaire +2 more sources
The cardiac pacemakers: A paradigm of robustness in evolutionary biology
The Journal of Physiology, EarlyView.Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley +1 more source
PO-01-152 REDUCED ACETYLCHOLINE-ACTIVATED POTASSIUM CURRENT IN THE SINOATRIAL NODE CONTRIBUTES TO ACCELERATED CARDIAC AUTOMATICITY IN PREGNANCY [PDF]
, 2023 Valérie Long, Céline Fiset
openalex +1 more source
Potassium channels in the sinoatrial node and their role in heart rate control
Channels, 2018 Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and ...
Qadeer Aziz, Yiwen Li, A. Tinker
semanticscholar +1 more source
Structure mirroring function: What's the ‘matter’ with the funny current?
The Journal of Physiology, EarlyView.Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley +1 more source
Frontiers in Physiology, 2015 The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv +2 more
doaj +1 more source