Genetics of sinoatrial node function and heart rate disorders
Disease Models & Mechanisms, 2023 The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its electrical activation and ensuring that the heart's functional cardiac output meets physiological demand.
Lieve E. van der Maarel +2 more
doaj +3 more sources
Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +16 more
doaj +4 more sources
Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]
PLoS ONE, 2017 Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck +8 more
doaj +4 more sources
Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
Journal of Cardiovascular Development and Disease, 2021 Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of ...
Marietta Easterling +3 more
doaj +2 more sources
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]
Circulation, 2022 Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and ...
Zheng M +14 more
europepmc +2 more sources
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas [PDF]
bioRxiv, 2021 Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results.
Peter Hanna +23 more
openalex +2 more sources
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +2 more sources
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
Nature Communications, 2021 The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit ...
Dandan Liang +15 more
doaj +2 more sources
Nature Communications, 2020 The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their ...
Ning Li +20 more
doaj +2 more sources
Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF. [PDF]
JACC Clin ElectrophysiolManning D +12 more
europepmc +3 more sources