Results 11 to 20 of about 1,321,275 (276)

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Circulation Research, 2022
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia.
Yuling Han, Jiajun Zhu, Liuliu Yang, Benjamin E. Nilsson-Payant, Romulo Hurtado, Lauretta A. Lacko, Xiaolu Sun, Aravind R. Gade, Christina A. Higgins, Whitney J. Sisso, Xue Dong, Maple Wang, Zhengming Chen, D. Ho, G. Pitt, R. Schwartz, B. tenOever, T. Evans, Shuibing Chen   +18 more
semanticscholar   +1 more source

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

Nature Communications, 2021
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the contraction of the heart in mammals. Though discovered over a century ago, the molecular and cellular features of the SAN that underpin its critical function in ...
Dandan Liang, Jinfeng Xue, Li Geng, Liping Zhou, Bo Lv, Qiao Zeng, Ke Xiong, Huixing Zhou, Duanyang Xie, Fulei Zhang, Jie Liu, Yi Liu, Li Li, Jian Yang, Zhigang Xue, Yi-Han Chen   +15 more
semanticscholar   +1 more source

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN).
T. Mesquita, Rui Zhang, J. Cho, Rui Zhang, Yen-Nien Lin, L. Sanchez, J. Goldhaber, Joseph Yu, Jialiu A. Liang, Weixin Liu, N. Trayanova, E. Cingolani   +11 more
semanticscholar   +1 more source

Lithium-Induced Sinoatrial Node Dysfunction [PDF]

Cureus, 2021
Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Ashish Sarangi, Wail Amor, Tanya Paul, Sana Javed   +3 more
openaire   +2 more sources

The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability

Function, 2021
The cardiac cycle starts when an action potential is produced by pacemaking cells in the sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million times in mice per day, imposing a monumental metabolic demand on the ...
N. Grainger, L. Guarina, Robert H. Cudmore, L., Fernando Santana   +4 more
semanticscholar   +1 more source

Tongyang Huoxue Decoction (TYHX) Ameliorating Hypoxia/Reoxygenation-Induced Disequilibrium of Calcium Homeostasis and Redox Imbalance via Regulating Mitochondrial Quality Control in Sinoatrial Node Cells

Oxidative Medicine and Cellular Longevity, 2021
Sick sinus syndrome (SSS) is a disease with bradycardia or arrhythmia. The pathological mechanism of SSS is mainly due to the abnormal conduction function of the sinoatrial node (SAN) caused by interstitial lesions or fibrosis of the SAN or surrounding ...
X. Chang, S. Yao, Qiaomin Wu, Yanli Wang, Jinfeng Liu, Ruxiu Liu   +5 more
semanticscholar   +1 more source

Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue.
A. Kalyanasundaram, Ning Li, Miranda L Gardner, Esthela J. Artiga, Brian J. Hansen, A. Webb, Michael A. Freitas, Maciej Pietrzak, B. Whitson, N. Mokadam, P. Janssen, P. Mohler, V. Fedorov   +12 more
semanticscholar   +1 more source

Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node

Scientific Reports, 2021
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression.
Ning Li, Esthela J. Artiga, A. Kalyanasundaram, Brian J. Hansen, A. Webb, Maciej Pietrzak, B. Biesiadecki, B. Whitson, N. Mokadam, Paul M L Janssen, J. Hummel, P. Mohler, H. Dobrzynski, V. Fedorov   +13 more
semanticscholar   +1 more source

Sinoatrial-Node Entrance Block [PDF]

Circulation, 1971
Sinus-node function was characterized in 13 patients during cardiac catheterization by the introduction of progressively premature atrial depolarizations. Curves relating the extent of sinus-node depression following these premature depolarizations and their degree of prematurity were constructed.
Bruce N. Goldreyer, Anthony N. Damato
openaire   +3 more sources

Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The funny current (If) is critical for spontaneous activity in cardiac pacemaker cells; however, its precise role remains enigmatic because it activates mostly outside the physiological voltage range and its kinetics are slow relative to the
C. Peters, Pin W. Liu, S. Morotti, Stephanie C. Gantz, E. Grandi, B. Bean, C. Proenza   +6 more
semanticscholar   +1 more source