Results 11 to 20 of about 1,311,541 (283)
Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity [PDF]
Frontiers in Cardiovascular Medicine, 2021 The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner +6 more
doaj +6 more sources
Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]
Frontiers in PhysiologyBackground: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci +4 more
doaj +2 more sources
Atrial and Sinoatrial Node Development in the Zebrafish Heart
Journal of Cardiovascular Development and Disease, 2021 Proper development and function of the vertebrate heart is vital for embryonic and postnatal life. Many congenital heart defects in humans are associated with disruption of genes that direct the formation or maintenance of atrial and pacemaker ...
Kendall E. Martin, Joshua S. Waxman
doaj +2 more sources
Function and dysfunction of human sinoatrial node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core +6 more sources
Is sodium current present in human sinoatrial node cells? [PDF]
International Journal of Biological Sciences, 2009 Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa) plays a role in the pacemaker activity of the human ...
Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
doaj +4 more sources
Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
doaj +2 more sources
Pharmacologic Approach to Sinoatrial Node Dysfunction.
Annual Review of Pharmacology and Toxicology, 2020 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sinoatrial node dysfunction (SND) and sick sinoatrial syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential.
P. Mesirca +6 more
semanticscholar +4 more sources
CaMKII in sinoatrial node physiology and dysfunction
Frontiers in Pharmacology, 2014 The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu +2 more
doaj +3 more sources
Telocytes in the human sinoatrial node [PDF]
Journal of Cellular and Molecular Medicine, 2017 The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells.
L. Mitrofanova +3 more
semanticscholar +4 more sources