Results 21 to 30 of about 1,311,541 (283)

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +2 more sources

The sinoatrial node, a heterogeneous pacemaker structure [PDF]

Cardiovascular Research, 2000
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing.
Mark R. Boyett
openalex   +4 more sources

Computer modelling of the sinoatrial node [PDF]

Medical & Biological Engineering & Computing, 2007
Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
Ronald Wilders
openalex   +5 more sources

Genetics of sinoatrial node function and heart rate disorders

Disease Models & Mechanisms, 2023
Lieve E. van der Maarel, Alex V. Postma, Vincent M. Christoffels   +2 more
doaj   +2 more sources

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Circulation Research, 2022
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia.
Yuling Han, Jiajun Zhu, Liuliu Yang, Benjamin E. Nilsson-Payant, Romulo Hurtado, Lauretta A. Lacko, Xiaolu Sun, Aravind R. Gade, Christina A. Higgins, Whitney J. Sisso, Xue Dong, Maple Wang, Zhengming Chen, D. Ho, G. Pitt, R. Schwartz, B. tenOever, T. Evans, Shuibing Chen   +18 more
semanticscholar   +1 more source

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]

PLoS ONE, 2014
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj   +1 more source

Junctional Pacemaker May Replace the Sinoatrial Node

Cardiovascular Innovations and Applications, 2021
Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin, Yuqin Xiong, Yipin Lin, Yuhua Li, Lijuan Zhang   +4 more
doaj   +1 more source

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source

Myoarchitecture of the Sinoatrial Node and its Relevance for Catheter Ablation: Anatomy and Histology. [PDF]

JACC Case Rep
Restrepo AJ, Razminia M, Sánchez-Quintana D, Cabrera JÁ.   +3 more
europepmc   +3 more sources

The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability

Function, 2021
The cardiac cycle starts when an action potential is produced by pacemaking cells in the sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million times in mice per day, imposing a monumental metabolic demand on the ...
N. Grainger, L. Guarina, Robert H. Cudmore, L., Fernando Santana   +4 more
semanticscholar   +1 more source