Results 21 to 30 of about 9,952 (192)

SCN5A and sinoatrial node pacemaker function [PDF]

Cardiovascular Research, 2007
The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells.
Lei, Ming, Zhang, Henggui, Grace, Andrew A., Huang, Christopher L H   +3 more
openaire   +2 more sources

Telocytes in the human sinoatrial node [PDF]

Journal of Cellular and Molecular Medicine, 2017
AbstractThe sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile ...
Lubov B. Mitrofanova, Andrey N. Gorshkov, Petr V. Konovalov, Julia S. Krylova   +3 more
openaire   +2 more sources

Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans

Frontiers in Physiology, 2020
The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald, Robert A. Rose, T. Alexander Quinn, T. Alexander Quinn   +3 more
doaj   +1 more source

Pathophysiological Significance of T-type Ca2+ Channels: Properties and Functional Roles of T-type Ca2+ Channels in Cardiac Pacemaking

Journal of Pharmacological Sciences, 2005
Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj   +1 more source

Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]

Circulation, 2022
Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and function.
Zheng M, Li RG, Song J, Zhao X, Tang L, Erhardt S, Chen W, Nguyen BH, Li X, Li M, Wang J, Evans SM, Christoffels VM, Li N, Wang J.   +14 more
europepmc   +3 more sources

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Thomas A. Csepe, Jichao Zhao, Brian J. Hansen, Ning Li, Lidiya V. Sul, Praise Lim, Yufeng Wang, Orlando P. Simonetti, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Vadim V. Fedorov   +11 more
openaire   +3 more sources

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +1 more source

Emerging Signaling Regulation of Sinoatrial Node Dysfunction. [PDF]

Curr Cardiol Rep, 2023
The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Zheng M, Erhardt S, Cao Y, Wang J.
europepmc   +3 more sources

Pathophysiology of Cav1.3 L-type calcium channels in the heart

Frontiers in Physiology, 2023
Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri, Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Yongxia Sarah Qu, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Chahine, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +10 more
doaj   +1 more source

Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node

Revista Facultad de Ingeniería Universidad de Antioquia, 2013
A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett.
Daniel Alfonso Sierra, Oscar Leonel Rueda, Carlos Rodrigo Correa   +2 more
doaj   +1 more source