Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity
The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner+6 more
doaj +1 more source
Computer Algorithms for Automated Detection and Analysis of Local Ca2+ Releases in Spontaneously Beating Cardiac Pacemaker Cells [PDF]
Local Ca Releases (LCRs) are crucial events involved in cardiac pacemaker cell function. However, specific algorithms for automatic LCR detection and analysis have not been developed in live, spontaneously beating pacemaker cells. Here we measured LCRs using a high-speed 2D-camera in spontaneously contracting sinoatrial (SA) node cells isolated from ...
arxiv +1 more source
The effect of the number of mobile nodes on varying speeds of manets [PDF]
Mobile Ad hoc Networks are dynamic networks populated by mobile devices, or mobile nodes.The Mobile Nodes are free to move anywhere and at any time. The population of the nodes may have some influence on the mobility rate of the mobile nodes. This paper presents simulation results using Matrix Laboratory software.
arxiv +1 more source
The aim of the study was to develop a three-dimensional (3D) anatomically-detailed model of the rabbit right atrium containing the sinoatrial and atrioventricular nodes to study the electrophysiology of the nodes. A model was generated based on 3D images
Jue Li+5 more
doaj +1 more source
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]
Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj +2 more sources
Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity [PDF]
It has become widely accepted that the most dangerous cardiac arrhythmias are due to re- entrant waves, i.e., electrical wave(s) that re-circulate repeatedly throughout the tissue at a higher frequency than the waves produced by the heart's natural pacemaker (sinoatrial node). However, the complicated structure of cardiac tissue, as well as the complex
arxiv +1 more source
The Distance Distribution between Mobile Node and Reference Node in Regular Hexagon [PDF]
This paper presents a new method to obtain the distance distribution between the mobile node and any reference node in a regular hexagon. The existing distance distribution research mainly focuses on static network deployment and ignores node mobility. This paper studies the distribution of node distances between mobile node and any reference node.
arxiv
Background: Dexmedetomidine (Dex) is widely used, and its most common side effect is bradycardia. The complete mechanism through which Dex induces bradycardia has not been elucidated.
Yong-Qiang Yin+3 more
doaj
Mathematical Models of Cardiac Pacemaking Function
Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling;
Pan eLi+3 more
doaj +1 more source
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit ...
Dandan Liang+15 more
doaj +1 more source