Results 21 to 30 of about 1,344,270 (316)

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]

Nature Communications
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim, Delaram Pouyabahar, Mishal Ashraf, Kate Huang, Michelle Lohbihler, Brandon M. Murareanu, Matthew L. Chang, Maggie Kwan, Faisal J. Alibhai, Thinh Tran, Amine Mazine, Michael A. Laflamme, Gary D. Bader, Zachary Laksman, Stephanie Protze   +14 more
doaj   +2 more sources

Translational Anatomy of the Sinoatrial Node [PDF]

JACC: Case Reports
Alejandro Jiménez Restrepo, MD, Mansour Razminia, MD, Damián Sánchez-Quintana, MD, PhD, José-Ángel Cabrera Rodriguez, MD, PhD   +3 more
doaj   +3 more sources

Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]

Frontiers in Physiology
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci, Fazeelat Mazhar, Moreno Marzolla, Stefano Severi, Chiara Bartolucci   +4 more
doaj   +2 more sources

Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity

Frontiers in Cardiovascular Medicine, 2021
The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner, Chen Kang, Pietro Mesirca, Juan Hong, Matteo E. Mangoni, Alexey V. Glukhov, Rajan Sah   +6 more
doaj   +2 more sources

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +2 more sources

Pharmacologic Approach to Sinoatrial Node Dysfunction.

Annual Review of Pharmacology and Toxicology, 2020
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sinoatrial node dysfunction (SND) and sick sinoatrial syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential.
P. Mesirca, V. Fedorov, T. Hund, A. Torrente, I. Bidaud, P. Mohler, M. Mangoni   +6 more
semanticscholar   +4 more sources

CaMKII in sinoatrial node physiology and dysfunction

Frontiers in Pharmacology, 2014
The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu, Mark E Anderson, Mark E Anderson   +2 more
doaj   +3 more sources

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +2 more sources

Function and dysfunction of human sinoatrial node [PDF]

Korean Circulation Journal, 2015
Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core   +5 more sources

Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node. [PDF]

Front Med (Lausanne)
Jorge Tasé DA, Garavaglia L, Defeo MM, Irurzun IM.   +3 more
europepmc   +3 more sources