Results 21 to 30 of about 70,541 (271)
Telocytes in the human sinoatrial node [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractThe sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile ...
Lubov B. Mitrofanova +3 more
openaire +3 more sources
Models of the cardiac L‐type calcium current: A quantitative review
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 We discuss 73 published models of mammalian ICaL and find differences in gating kinetics, electrochemical driving force, and sensitivity to internal calcium concentrations, leading to considerable variability in their predictions. Abstract The L‐type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital
Aditi Agrawal +7 more
wiley +1 more source
Sinoatrial-Node Entrance Block [PDF]
Circulation, 1971 Sinus-node function was characterized in 13 patients during cardiac catheterization by the introduction of progressively premature atrial depolarizations. Curves relating the extent of sinus-node depression following these premature depolarizations and their degree of prematurity were constructed.
Bruce N. Goldreyer, Anthony N. Damato
openaire +3 more sources
Bioscience Journal, 2020 Canine distemper is a viral disease that affects several systems on dogs, among them, the cardiovascular system. The aim of this study was to identify canine distemper virus (CDV) in the sinoatrial node (SAN) of dogs serologically positive for distemper ...
José Eugenio Diniz Bastos +4 more
doaj +3 more sources
Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]
PLoS ONE, 2017 Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck +8 more
doaj +1 more source
T-wave Inversion through Inhomogeneous Voltage Diffusion within the FK3V Cardiac Model [PDF]
Chaos 34, 043140 (2024), 2023 The heart beats due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart's electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably ...
arxiv +1 more source
Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
Sinus automaticity and sinoatrial conduction in severe symptomatic sick sinus syndrome [PDF]
, 1992 Electrophysiologic studies with recordings of sinus node electrograms were performed in 38 patients with severe symptomatic sick sinus syndrome. Thirty-two of the 38 patients had episodic tachyarrhythmias and 17 presented with syncope.
Cherng, Wen-Jin +4 more
core +1 more source
Pharmacologic Approach to Sinoatrial Node Dysfunction
Annual Review of Pharmacology and Toxicology, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Mesirca, Pietro +6 more
openaire +4 more sources
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +1 more source