Results 31 to 40 of about 1,311,541 (283)

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN).
T. Mesquita, Rui Zhang, J. Cho, Rui Zhang, Yen-Nien Lin, L. Sanchez, J. Goldhaber, Joseph Yu, Jialiu A. Liang, Weixin Liu, N. Trayanova, E. Cingolani   +11 more
semanticscholar   +1 more source

Tongyang Huoxue Decoction (TYHX) Ameliorating Hypoxia/Reoxygenation-Induced Disequilibrium of Calcium Homeostasis and Redox Imbalance via Regulating Mitochondrial Quality Control in Sinoatrial Node Cells

Oxidative Medicine and Cellular Longevity, 2021
Sick sinus syndrome (SSS) is a disease with bradycardia or arrhythmia. The pathological mechanism of SSS is mainly due to the abnormal conduction function of the sinoatrial node (SAN) caused by interstitial lesions or fibrosis of the SAN or surrounding ...
X. Chang, S. Yao, Qiaomin Wu, Yanli Wang, Jinfeng Liu, Ruxiu Liu   +5 more
semanticscholar   +1 more source

Lithium-Induced Sinoatrial Node Dysfunction. [PDF]

Cureus, 2021
Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi A, Javed S, Paul T, Amor W.
europepmc   +4 more sources

Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node

Scientific Reports, 2021
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression.
Ning Li, Esthela J. Artiga, A. Kalyanasundaram, Brian J. Hansen, A. Webb, Maciej Pietrzak, B. Biesiadecki, B. Whitson, N. Mokadam, Paul M L Janssen, J. Hummel, P. Mohler, H. Dobrzynski, V. Fedorov   +13 more
semanticscholar   +1 more source

Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons

Protein & Cell, 2021
Activation of the heart normally begins in the sinoatrial node (SAN). Electrical impulses spontaneously released by SAN pacemaker cells (SANPCs) trigger the contraction of the heart. However, the cellular nature of SANPCs remains controversial.
Dandan Liang, Zhigang Xue, Jinfeng Xue, Duanyang Xie, Ke Xiong, Huixing Zhou, Fulei Zhang, Xuling Su, Guanghua Wang, Qicheng Zou, Yi Liu, Jian Yang, Honghui Ma, Luying Peng, C. Zeng, Gang Li, Li Wang, Yi-Han Chen   +17 more
semanticscholar   +1 more source

Sinoatrial-Node Entrance Block [PDF]

Circulation, 1971
Sinus-node function was characterized in 13 patients during cardiac catheterization by the introduction of progressively premature atrial depolarizations. Curves relating the extent of sinus-node depression following these premature depolarizations and their degree of prematurity were constructed.
Bruce N. Goldreyer, Anthony N. Damato
openaire   +3 more sources

Anatomopathological changes in canine distemper seropositive dogs and virus detection in sinoatrial nodes

Bioscience Journal, 2020
Canine distemper is a viral disease that affects several systems on dogs, among them, the cardiovascular system. The aim of this study was to identify canine distemper virus (CDV) in the sinoatrial node (SAN) of dogs serologically positive for distemper ...
José Eugenio Diniz Bastos, Neide Maria Silva, Marisol Patrícia Pallete Briceño, Tais Meziara Wilson, Alessandra Aparecida Medeiros-Ronchi   +4 more
doaj   +3 more sources

Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue.
A. Kalyanasundaram, Ning Li, Miranda L Gardner, Esthela J. Artiga, Brian J. Hansen, A. Webb, Michael A. Freitas, Maciej Pietrzak, B. Whitson, N. Mokadam, P. Janssen, P. Mohler, V. Fedorov   +12 more
semanticscholar   +1 more source

Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The funny current (If) is critical for spontaneous activity in cardiac pacemaker cells; however, its precise role remains enigmatic because it activates mostly outside the physiological voltage range and its kinetics are slow relative to the
C. Peters, Pin W. Liu, S. Morotti, Stephanie C. Gantz, E. Grandi, B. Bean, C. Proenza   +6 more
semanticscholar   +1 more source

Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas

bioRxiv, 2020
Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results.
Peter Hanna, M. Dacey, J. Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, M. A. Swid, Pradeep S. Rajendran, Shumpei Mori, Joseph E. Hadaya, Elizabeth H. Smith, Stanley G. Peirce, Jin Chen, L. Havton, Z. Cheng, R. Vadigepalli, J. Schwaber, R. Lux, I. Efimov, J. Tompkins, D. Hoover, J. Ardell, K. Shivkumar   +23 more
semanticscholar   +1 more source