Results 31 to 40 of about 11,359 (232)

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Nature Communications, 2020
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their ...
Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul ML. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov   +20 more
doaj   +1 more source

Do human sinoatrial node cells have t-tubules?

Translational Research in Anatomy, 2021
Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca2+ clocks, regulated by strictly ...
Maria A. Petkova, Halina Dobrzynski
doaj   +1 more source

Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node) [PDF]

Research Results in Pharmacology, 2021
Introduction: Cardiac pacing is indicated for sick sinus syndrome. It is performed with a pacemaker via electrodes implanted in the heart. This technique has several disadvantages. The search for alternative methods of cardiac pacing is underway.
Pavel A. Galenko-Yaroshevsky, Anatoly A. Nechepurenko, Tatiana G. Pokrovskaya, Nikolai L. Shimonovsky, Alexander S. Dukhanin, Konstantin F. Suzdalev, Polina D. Maslova, Natalia M. Makhnova, Vadim V. Shneivais, Valery G. Abushkevich, Anait V. Zelenskaya, Valeria V. Seletskaya, Saida K. Ahedzhak-Naguse, Konstantin G. Korotkov   +13 more
doaj   +3 more sources

Pharmacologic Approach to Sinoatrial Node Dysfunction

Annual Review of Pharmacology and Toxicology, 2021
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Thomas J. Hund, Vadim V. Fedorov, Isabelle Bidaud, Peter J. Mohler, Matteo E. Mangoni, Angelo G. Torrente, P. Mesirca   +6 more
openaire   +3 more sources

SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation

Regenerative Therapy, 2022
Introduction: Dysfunction of the sinoatrial node (SAN) cells causes arrhythmias, and many patients require artificial cardiac pacemaker implantation. However, the mechanism of impaired SAN automaticity remains unknown, and the generation of human SAN ...
Takayuki Wakimizu, Kumi Morikawa, Kenta Fukumura, Tetsuo Yuki, Takashi Adachi, Yasutaka Kurata, Junichiro Miake, Ichiro Hisatome, Motokazu Tsuneto, Yasuaki Shirayoshi   +9 more
doaj   +1 more source

Gap junctions in the rabbit sinoatrial node [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2001
In comparison to the cellular basis of pacemaking, the electrical interactions mediating synchronization and conduction in the sinoatrial node are poorly understood. Therefore, we have taken a combined immunohistochemical and electrophysiological approach to characterize gap junctions in the nodal area.
Marjan J. A. van Kempen, Sjoerd Postma, Habo J. Jongsma, Martin B. Rook, Sander Verheule   +4 more
openaire   +3 more sources

Genetic Abnormalities of the Sinoatrial Node and Atrioventricular Conduction

Cardiac Electrophysiology Clinics, 2021
The peculiar electrophysiological properties of the sinoatrial node and the cardiac conduction system are key components of the normal physiology of cardiac impulse generation and propagation. Multiple genes and transcription factors and metabolic proteins are involved in their development and regulation.
Porta Sánchez, Andreu, Giuliana Priori, Silvia   +1 more
openaire   +6 more sources

Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]

PeerJ, 2017
Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj   +2 more sources

Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node

Journal of Pharmacological Sciences, 2004
Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node ...
Kentaro Takeda, Reiko Yamagishi, Haruko Masumiya, Hikaru Tanaka, Koki Shigenobu   +4 more
doaj   +1 more source

Bioelectronic Sensors for Neuromuscular Perception in Human‐Machine Interfaces

Advanced Robotics Research, EarlyView.
This review summarizes recent advances in bioelectronic sensors for neuromuscular perception in human‐machine interfaces. By integrating biopotential, electrical impedance, and electrochemical sensing strategies with flexible electrode interfaces, these bioelectronic sensing systems enable intuitive, real‐time detection of muscle and nerve activity ...
Junwei Li, Bangyan Niu, Kunlin Wu, Jingcheng Xiao, Xiaoyan Liu, Yifan Wang   +5 more
wiley   +1 more source