SCN5A and sinoatrial node pacemaker function [PDF]
Cardiovascular Research, 2007 The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells.
Lei, Ming +3 more
openaire +3 more sources
The World Congress of Insulin Resistance, Diabetes and Cardiovascular Disease (WCIRDC)
, 2023 Journal of Diabetes, Volume 15, Issue 1, Page 4-6, January 2023.
Zachary T. Bloomgarden
wiley +1 more source
Histopathological changes in the electrical conduction of cardiac nodes after acute myocardial infarction in dogs and horses, compared with findings in humans: A histological, morphometrical, and immunohistochemical study [PDF]
Veterinary World, 2023 Background and Aim: The heart conduction system is responsible for the occurrence of various types of cardiac arrhythmia. This study aimed to histologically and morphometrically describe damaged cardiac nodes during acute myocardial infarction and to ...
Fabián Gómez-Torres +2 more
doaj +1 more source
Tbx18 and the generation of a biological pacemaker. Are we there yet? [PDF]
, 2016 A group of approximately 10,000 cells in the sinoatrial node (SAN), which is located at the entry of the right superior caval vein into the right atrium, is responsible for regular heart beating under different physiological conditions [1]. While the SAN
Brand, T
core +1 more source
Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
doaj +1 more source
Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases [PDF]
, 2020 Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Asano, Yoshihiro +44 more
core +1 more source
Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. [PDF]
, 2013 The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), depolarization by cardiac Na-Ca ...
Alber, Sarah +13 more
core +2 more sources
Pathophysiology of Cav1.3 L-type calcium channels in the heart
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
doaj +1 more source
Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta [PDF]
, 1993 Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney.
Ahmad +27 more
core +1 more source
Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node
Revista Facultad de Ingeniería Universidad de Antioquia, 2013 A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett.
Daniel Alfonso Sierra +2 more
doaj +1 more source