Results 31 to 40 of about 22,194 (282)

Telocytes in the human sinoatrial node [PDF]

Journal of Cellular and Molecular Medicine, 2017
AbstractThe sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile ...
Lubov B. Mitrofanova, Andrey N. Gorshkov, Petr V. Konovalov, Julia S. Krylova   +3 more
openaire   +2 more sources

Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans

Frontiers in Physiology, 2020
The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald, Robert A. Rose, T. Alexander Quinn, T. Alexander Quinn   +3 more
doaj   +1 more source

Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling [PDF]

, 2006
Cardiac and uterine muscle cells and tissue can be either autorhythmic or excitable. These behaviours exchange stability at bifurcations produced by changes in parameters, which if spatially localized can produce an ectopic pacemaking focus.
Benson, A.P., Clayton, R.H., Holden, A.V., Kharche, S., Tong, W.C.   +4 more
core   +1 more source

Pathophysiological Significance of T-type Ca2+ Channels: Properties and Functional Roles of T-type Ca2+ Channels in Cardiac Pacemaking

Journal of Pharmacological Sciences, 2005
Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj   +1 more source

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Thomas A. Csepe, Jichao Zhao, Brian J. Hansen, Ning Li, Lidiya V. Sul, Praise Lim, Yufeng Wang, Orlando P. Simonetti, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Vadim V. Fedorov   +11 more
openaire   +3 more sources

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +1 more source

Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. [PDF]

, 2013
The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), depolarization by cardiac Na-Ca ...
Alber, Sarah, Goldhaber, Joshua I, Groenke, Sabine, Jordan, Maria C, Karagueuzian, Hrayr S, Lamp, Scott T, Larson, Eric D, Nakano, Atsushi, Nakano, Haruko, Philipson, Kenneth D, Proenza, Catherine, Ren, Xiaoyan, Roos, Kenneth P, Zhang, Rui   +13 more
core   +2 more sources

Pathophysiology of Cav1.3 L-type calcium channels in the heart

Frontiers in Physiology, 2023
Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri, Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Yongxia Sarah Qu, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Chahine, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +10 more
doaj   +1 more source

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]

, 1982
These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M., Erlanger, Bernard F., Lester, Henry A., Nargeot, Joel, Stockton, Jane, Wassermann, Norbert H.   +5 more
core   +1 more source

The early stages of heart development: insights from chicken embryos [PDF]

, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan, Arguello, de la Cruz, de La Cruz, de la Cruz, DeHaan, Hatada, Kitajima, Le Lievre, Needham, Plein, Psychoyos, Rosenquist, Schultheiss, Stern, Tam, Vincent, Waldo, Yatskievych, Zhang   +19 more
core   +2 more sources