Results 51 to 60 of about 22,194 (282)
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
PLoS ONE, 2014 The aim of the study was to develop a three-dimensional (3D) anatomically-detailed model of the rabbit right atrium containing the sinoatrial and atrioventricular nodes to study the electrophysiology of the nodes. A model was generated based on 3D images
Jue Li +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node ...
Kentaro Takeda +4 more
doaj +1 more source
Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity
Frontiers in Cardiovascular Medicine, 2021 The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner +6 more
doaj +1 more source
The Sinoatrial Node: Cell Size Does Matter [PDF]
Circulation Research, 2007 To the Editor: The key point of the recently published report in Circulation Research 1 by Lyashkov et al is that action potential characteristics (including beating rate) and Ca2+ handling are independent of the size of the sinoatrial node (SAN) cell in the rabbit.
Boyett, M. R. +6 more
openaire +1 more source
Health Care Science, EarlyView.Heart Rate Variability Estimation from Camera Videos ABSTRACT Background Studies have shown that heart rate variability (HRV) is a predictor of the prognosis of cardiovascular diseases. Contact heartbeat monitoring equipment is widely used, especially in hospitals, and benefits from the rapidity and accuracy of the detection of physiological health ...
Lan Lan +8 more
wiley +1 more source
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]
PeerJ, 2017 Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj +2 more sources
International Journal of Cancer, EarlyView.Abstract The integration of modern systemic therapies with radiotherapy (RT) represents a promising strategy in breast cancer management, enhancing both locoregional control and systemic disease outcomes. This expert consensus from the Institut Curie Breast Radiotherapy Group focuses exclusively on modern systemic agents, synthesizing current evidence ...
Cezara Cheptea +5 more
wiley +1 more source
Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart [PDF]
, 2014 Fiber-optics confocal microscopy (FCM) is an emerging imaging technology with various applications in basic research and clinical diagnosis. FCM allows for real-time in situ microscopy of tissue at sub-cellular scale.
Aditya K. Kaza +4 more
core +2 more sources
Mathematical Models of Cardiac Pacemaking Function
Frontiers in Physics, 2013 Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling;
Pan eLi +3 more
doaj +1 more source