Results 81 to 90 of about 1,321,275 (276)
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart [PDF]
, 2015 With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes.
Close, Graeme L. +6 more
core +2 more sources
Journal of Biological Chemistry, 2018 ATP-sensitive potassium channels (KATP) contribute to membrane currents in many tissues, are responsive to intracellular metabolism, and open as ATP falls and ADP rises. KATP channels are widely distributed in tissues and are prominently expressed in the
Qadeer Aziz +7 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Journal of Diabetes Research, 2018 Background In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of ...
F. Howarth +6 more
semanticscholar +1 more source
The cardiac pacemakers: A paradigm of robustness in evolutionary biology
The Journal of Physiology, EarlyView.Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley +1 more source
Structure mirroring function: What's the ‘matter’ with the funny current?
The Journal of Physiology, EarlyView.Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley +1 more source
Reversibility of both sinus node dysfunction and reduced HCN4 mRNA expression level in an atrial tachycardia pacing model of tachycardia-bradycardia syndrome in rabbit hearts [PDF]
, 2016 published_or_final_versio
Chen, Z, Jiang, J, Sun, B, Tse, G, Xu, W
core
Pregnancy and oestrogen regulate sinoatrial node calcium homeostasis and accelerate pacemaking
Cardiovascular Research, 2018 Aims During pregnancy, there is a significant increase in heart rate (HR) potentially associated with an increased risk of arrhythmias or exacerbation of pre-existing cardiac conditions endangering both mother and foetus.
Nabil El Khoury +5 more
semanticscholar +1 more source
Models of cardiomyocyte–non‐myocyte electrical interactions
The Journal of Physiology, EarlyView.Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica +2 more
wiley +1 more source