Results 1 to 10 of about 10,441 (208)

Genetic Complexity of Sinoatrial Node Dysfunction [PDF]

Frontiers in Genetics, 2021
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace, Michael J. Wallace, Michael J. Wallace, Mona El Refaey, Mona El Refaey, Mona El Refaey, Pietro Mesirca, Pietro Mesirca, Thomas J. Hund, Thomas J. Hund, Thomas J. Hund, Matteo E. Mangoni, Matteo E. Mangoni, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +16 more
doaj   +5 more sources

Possible sinoatrial node dysfunction in a 6-month-old domestic shorthair cat [PDF]

Journal of Feline Medicine and Surgery Open Reports
Case summary A 6-month-old male entire domestic shorthair cat was presented to the ophthalmology department for nasolacrimal duct cannulation and flushing, and castration under general anaesthesia.
Florence Hillen, Laurent Locquet
doaj   +4 more sources

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation [PDF]

JCI Insight, 2022
Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21
Roberto Ramos-Mondragon, Nnamdi Edokobi, Samantha L. Hodges, Shuyun Wang, Alexandra A. Bouza, Chandrika Canugovi, Caroline Scheuing, Lena Juratli, William R. Abel, Sami F. Noujaim, Nageswara R. Madamanchi, Marschall S. Runge, Luis F. Lopez-Santiago, Lori L. Isom   +13 more
doaj   +4 more sources

Insulin mitigates acute ischemia–induced atrial fibrillation and sinoatrial node dysfunction ex vivo [PDF]

JCI Insight
Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood.
Huiliang Qiu, Fan Li, Hannah Prachyl, Alejandra Patino-Guerrero, Michael Rubart, Wuqiang Zhu   +5 more
doaj   +4 more sources

Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction [PDF]

Experimental Physiology
Millions of people are affected by atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF), two disorders frequently found simultaneously. However, the interrelationship between these intertwined disorders is poorly understood,
Bernadin Ndongson‐Dongmo, Reinhard Bauer, Finn Olav Levy   +2 more
doaj   +3 more sources

Digenic heterozygous mutations of KCNH2 and SCN5A induced young and early‐onset long QT syndrome and sinoatrial node dysfunction [PDF]

Annals of Noninvasive Electrocardiology, 2022
Introduction Long QT syndrome (LQTS) is a life‐threatening inherited channelopathy, and prolonged QT intervals easily trigger malignant arrhythmias, especially torsades de pointes and ventricular fibrillation.
Zhe Yang, Yuting Ma, Jiana Huang, Jianzhong Xian, Yin Huang, Linbo Wu, WenLiang Zhu, Feng Wang, Liang Chen, Xiufang Lin, Yubi Lin   +10 more
doaj   +2 more sources

Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]

Frontiers in Cardiovascular Medicine
Pulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang, Enyuan Zhang, Le He, Henan Zhang, Jing Xu, Fengmin Lu, Dongyan Wu, Yitong Yin, Wei Ma   +8 more
doaj   +2 more sources

Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction [PDF]

Journal of Cardiovascular Development and Disease, 2022
Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022,
Weijie Chen, Zengzhang Liu, Peilin Xiao, Yanping Xu, Dan Li, Qingsong Xiong, Lili Zou, Fang Qin, Xiexin Tao, Junan Chen, Xianbin Lan, Huaan Du, Yuehui Yin, Zhiyu Ling   +13 more
doaj   +2 more sources

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models [PDF]

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +2 more sources

Sick Sinus Syndrome and Cerebral Venous Thrombosis: A Connection or Coincidence? A Case Report and Literature Review [PDF]

Oman Medical Journal
It has been hypothesized that increased intracranial pressure (ICP) may cause sick sinus syndrome (SSS) due to its effect on vagal discharge to the heart, resulting in disruption to the sinus cycle, despite age-related degeneration of the sinoatrial node
Alawi A. Al-Attas, Njood A. Alhrkan, Muteb A. Alwatid, Saifullah M. Zaman, Mohammed F. Salawaty, Nouf A. Mansour   +5 more
doaj   +2 more sources