Results 91 to 100 of about 10,441 (208)

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells [PDF]

, 2017
Background: Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular cardiomyocyte ...
Darche, Fabrice F., Draguhn, Andreas, Geschwill, Pascal, Greber, Boris, Katus, Hugo A., Koenen, Michael, Müller-Decker, Karin, Rivinius, Rasmus, Schweizer, Patrick A., Seyler, Claudia, Thomas, Dierk, Ullrich, Nina D., Utikal, Jochen   +12 more
core   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Cardiovascular events follow-up analysis in patients with sinus node dysfunction and implanted pacemaker

Российский кардиологический журнал, 2019
Dysfunction of sinus node (DSN) is the syndrome, characterized by symptoms of tissue hypoperfusion and manifestations on the electrocardiogram and could potentially lead to sudden death. The various impact of different types of pacemakers on life quality
E. A. Badykova, M. R. Badykov, V. V. Plechev, I. Sh. Sagitov, I. A. Lakman, N. Sh. Zagidullin   +5 more
doaj   +1 more source

Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus. [PDF]

, 2016
This is the final version of the article. It first appeared from Hindawi via https://doi.org/10.1155/2016/2848759Diabetes is a common endocrine disorder with an ever increasing prevalence globally, placing significant burdens on our healthcare systems ...
Lai, Eric Tsz Him, Tse, Gary, Tse, Vivian, Yeo, Jie Ming   +3 more
core   +3 more sources

Unraveling the Complexities of Kartagener's Syndrome: A Case of Bronchiectasis, Isolated Dextrocardia, and Primary Ciliary Dyskinesia in an Adult With Chronic Respiratory Symptoms

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Kartagener's Syndrome (KS), a rare autosomal recessive disorder and a subset of Primary Ciliary Dyskinesia (PCD), is characterized by chronic sinusitis, bronchiectasis, and, in approximately 50% of cases, situs inversus. This condition arises from genetic mutations that impair motile cilia function, leading to defective mucociliary clearance ...
Ibrahim Khalil, Sakib Abrar, Shah Tanvir Ahmed, Md. Imran Hossain   +3 more
wiley   +1 more source

TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling [PDF]

, 2019
Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart ...
Calderón Sánchez, Eva María, Falcón Boyano, Débora, Galeano Otero, Isabel, Hmadcha, Abdelkrim, Martín Bórnez, Marta, Rosado, Juan Antonio, Smani Hajami, Tarik, Toro Estévez, Raquel del   +7 more
core   +1 more source

Cardiac Manifestations of KCNK17 Mutations and/or Polymorphisms: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The KCNK17 gene encodes k2p17.1 channels (TASK‐4 or TALK‐2) with dominant expressions in the atria and the Purkinje fibers. Emerging studies have suggested possible associations between KCNK17 variants and cardiovascular as well as cerebrovascular diseases. This review aimed to systematically evaluate the evidence on KCNK17
Amir Askarinejad, Mahshid Malakootian, Dorsa Shekouh, Amirreza Sabahizadeh, Majid Haghjoo   +4 more
wiley   +1 more source

CAROTID ARTERY STENTING IN A PATIENT WITH SINUS BRADYCARDIA: CLINICAL CASE

Рациональная фармакотерапия в кардиологии, 2018
Syndrome of hemodynamic depression is a frequent complication of the carotid artery endovascular intervention and, as a rule, is transient in nature. This article presents a clinical case of carotid artery stenting in a 63-year-old patient.
E. S. Bulgakova, T. V. Tvorogova, B. A. Rudenko, O. M. Drapkina   +3 more
doaj   +1 more source

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

JCI Insight, 2022
Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP.
Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat   +18 more
doaj   +1 more source

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

Frontiers in Physiology, 2020
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults.
Aaazh M. Alghamdi, Aaazh M. Alghamdi, Mark R. Boyett, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang   +7 more
doaj   +1 more source