Results 101 to 110 of about 10,441 (208)

Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs [PDF]

, 2016
It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this ...
Bogus, S. K., Galenko-Yaroshevskii, P. A., Kulikov, A. L., Suzdalev, K. P., Vinakov, D. V.   +4 more
core   +2 more sources

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, Volume 3, Issue 1, Page 47-68, March 2026.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Clinical characteristics and follow-up of complex arrhythmias associated with RYR2 gene mutations in children

Frontiers in Genetics
ObjectiveThe aim of this study was to analyze the diagnosis, treatment, and follow-up of six cases of complex arrhythmias associated with RYR2 gene mutations in children.MethodA retrospective analysis was conducted on six children diagnosed with complex ...
Yefeng Wang, Yufan Yang, Ningan Xu, Yunbin Xiao, Chao Zuo, Zhi Chen   +5 more
doaj   +1 more source

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the SCN5A-E161K Mutation and Role of the H558R Polymorphism

Frontiers in Physiology, 2018
Background: Carriers of the E161K mutation in the SCN5A gene, encoding the NaV1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (INa), show sinus bradycardia and occasional exit block.
Ronald Wilders
doaj   +1 more source

Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation [PDF]

, 2017
Background Skin sympathetic nerve activity (SKNA) is useful for estimating sympathetic tone in humans. Objective The purpose of this study was to test the hypotheses that (1) increased SKNA is associated with the onset and termination of ...
Chen, Lan S., Chen, Peng-Sheng, Doytchinova, Anisiia, Everett, Thomas H., IV, Lin, Andrew Y. T., Lin, Shien-Fong, Shen, Changyu, Uradu, Andrea, Wan, Juyi, Wright, Keith C.   +9 more
core   +1 more source

Should socioeconomic factors be considered as traditional risk factors for cardiovascular disease, as confounders, or as risk modifiers? [PDF]

, 2008
A large number of studies show that cardiovascular disease and its traditional risk factors are associated with socioeconomic conditions. However, their etiological role in the development of cardiovascular outcomes is not always well understood ...
De Vogli, R., Marmot, M.
core  

Cardiac‐specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility

Experimental Physiology, Volume 111, Issue 3, Page 1120-1133, 1 March 2026.
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Kelsey Halvorson, Man Si, Krystle Trosclair, Ellen Aughenbaugh, Maxine Parkinson, Nicole M. Gautier‐Hall, Megan Watts, Frederica Kizek, Md. Shenuarin Bhuiyan, Paari Dominic, Kathryn A. Hamilton, Edward Glasscock   +11 more
wiley   +1 more source

Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts. [PDF]

, 2018
Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype.
Akar, Antzelevitch, Arany, Bhuiyan, Billman, Boukens, Bovo, Brown, Brubaker, Bukowska, Chilton, Dai, Danik, Davies, Deo, Gazoti Debessa, Goldbarg, Gollob, Gurung, Huss, Jeevaratnam, Jeevaratnam, Jeevaratnam, Jeevaratnam, Jones, Kabunga, King, Kucharska-Newton, Lai, Lehman, Lelliott, Lin, Lin, Liu, Martin, Massumi, Mitchell, Mootha, Ning, Nisbet, Smyth, Sonoda, Sovari, Sullivan, Terentyev, Wang, Wu, Xie, Yan, Zhang, Zhang, Zoni-Berisso   +51 more
core   +1 more source

Selective sinoatrial node optical mapping and the mechanism of sinus rate acceleration [PDF]

, 2012
BACKGROUND: Studies using isolated sinoatrial node (SAN) cells indicate that rhythmic spontaneous sarcoplasmic reticulum calcium release (Ca clock) plays an important role in SAN automaticity.
Chen, Peng-Sheng, Chua, Su-Kiat, Han, Seongwook, Joung, Boyoung, Lin, Shien-Fong, Maruyama, Mitsunori, Park, Hyung-Wook, Shen, Mark J., Shinohara, Tetsuji   +8 more
core   +1 more source

Resting neuroendocrine markers in relation to acute mental stress‐induced adrenergic reactivity profiles in adults: The SABPA study

Physiological Reports, Volume 14, Issue 6, March 2026.
A grapical summary of predominant alpha and beta repsonders' neuroendocrine profile in the SABAP cohort. Abstract Stress‐induced hemodynamic reactivity was categorized as predominant alpha (α)‐ and beta (β)‐adrenergic reactivity profiles. Within these profiles, we investigated resting neuroendocrine markers, their associations with hemodynamic ...
Dewald Naudé, Wayne Smith, Roland von Känel, Annemarie Wentzel   +3 more
wiley   +1 more source