Results 11 to 20 of about 10,441 (208)
CaMKII in sinoatrial node physiology and dysfunction
Frontiers in Pharmacology, 2014 The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu +2 more
doaj +3 more sources
Function and dysfunction of human sinoatrial node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core +5 more sources
Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction [PDF]
Frontiers in Physiology, 2015 Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of ...
Thomas A Csepe +4 more
doaj +3 more sources
Lithium-Induced Sinoatrial Node Dysfunction. [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi A, Javed S, Paul T, Amor W.
europepmc +4 more sources
Pharmacologic Approach to Sinoatrial Node Dysfunction. [PDF]
Annu Rev Pharmacol Toxicol, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Mesirca P +6 more
europepmc +4 more sources
D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism. [PDF]
Aging (Albany NY), 2023 With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field.
Zhang H +13 more
europepmc +3 more sources
Emerging Signaling Regulation of Sinoatrial Node Dysfunction. [PDF]
Curr Cardiol Rep, 2023 The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Zheng M, Erhardt S, Cao Y, Wang J.
europepmc +3 more sources
Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction. [PDF]
Circulation, 2022 Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Mesquita T +11 more
europepmc +5 more sources
Medical Management of Hemodynamically Unstable Sinoatrial Node Dysfunction in a Patient With Intracardiac Lymphoma. [PDF]
JACC CardioOncol, 2021 [Figure: see text]
Martz CA +4 more
europepmc +3 more sources
Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. [PDF]
J Gerontol A Biol Sci Med Sci, 2022 Abstract Heart rate (HR) is controlled by the sinoatrial node (SAN). SAN dysfunction is highly prevalent in aging; however, not all individuals age at the same rate. Rather, health status during aging is affected by frailty. Natriuretic peptides regulate SAN function in part by activating natriuretic peptide receptor C (NPR-C).
Jansen HJ +4 more
europepmc +3 more sources