Results 11 to 20 of about 59,209 (214)

CaMKII in sinoatrial node physiology and dysfunction [PDF]

Frontiers in Pharmacology, 2014
The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu, Mark E Anderson, Mark E Anderson   +2 more
doaj   +4 more sources

D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism. [PDF]

Aging (Albany NY), 2023
With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field.
Zhang H, Chen C, Liu Y, Chen W, Qi J, Xu Y, Ren L, Yang G, Min D, Liu Z, Cai X, Hao M, Xu G, Hou P.   +13 more
europepmc   +5 more sources

Function and Dysfunction of Human Sinoatrial Node [PDF]

Korean Circulation Journal, 2015
Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Boyoung Joung, Peng‐Sheng Chen
core   +8 more sources

Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. [PDF]

J Gerontol A Biol Sci Med Sci, 2022
Abstract Heart rate (HR) is controlled by the sinoatrial node (SAN). SAN dysfunction is highly prevalent in aging; however, not all individuals age at the same rate. Rather, health status during aging is affected by frailty. Natriuretic peptides regulate SAN function in part by activating natriuretic peptide receptor C (NPR-C).
Jansen HJ, Moghtadaei M, Rafferty SA, Belke DD, Rose RA.   +4 more
europepmc   +5 more sources

Medical Management of Hemodynamically Unstable Sinoatrial Node Dysfunction in a Patient With Intracardiac Lymphoma. [PDF]

JACC CardioOncol, 2021
[Figure: see text]
Martz CA, Jarbeau JF, Castillo JJ, Fisher DC, Nohria A.   +4 more
europepmc   +5 more sources

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs [PDF]

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +4 more sources

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. [PDF]

Cardiovasc Diabetol, 2014
The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, patients with diabetes have faster heart rates compared to non-diabetic individuals, yet diabetic patients are frequently found among patients ...
Soltysinska E, Speerschneider T, Winther SV, Thomsen MB.   +3 more
europepmc   +8 more sources

Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction [PDF]

Journal of Cardiovascular Development and Disease, 2022
Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022,
Weijie Chen, Zengzhang Liu, Peilin Xiao, Yanping Xu, Dan Li, Qingsong Xiong, Lili Zou, Fang Qin, Xiexin Tao, Junan Chen, Xianbin Lan, Huaan Du, Yuehui Yin, Zhiyu Ling   +13 more
doaj   +4 more sources

Shenxian-Shengmai Oral Liquid Improves Sinoatrial Node Dysfunction through the PKC/NOX-2 Signaling Pathway. [PDF]

Evid Based Complement Alternat Med, 2021
Sick sinus syndrome (SSS) is one of the common causes of cardiac syncope and sudden death; the occurrence of SSS is associated with the accumulation of ROS in the sinoatrial node (SAN). Shenxian-shengmai (SXSM) is a traditional Chinese medicine available as oral liquid that causes a significant increase in heart rate.
Zhang H, Hao M, Li L, Chen K, Qi J, Chen W, Cai X, Chen C, Liu Z, Hou P.   +9 more
europepmc   +5 more sources

Insulin mitigates acute ischemia-induced atrial fibrillation and sinoatrial node dysfunction ex vivo. [PDF]

JCI Insight
Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood. In this study, ex vivo Langendorff perfusion was used to induce acute ischemia/reperfusion in the heart to mimic POAF. Inducibility of atrial fibrillation (AF)
Qiu H, Li F, Prachyl H, Patino-Guerrero A, Rubart M, Zhu W.   +5 more
europepmc   +3 more sources