Identification of CACNA1D variants associated with sinoatrial node dysfunction and deafness in additional Pakistani families reveals a clinical significance. [PDF]
J Hum Genet, 2019 Sinoatrial node dysfunction and deafness (SANDD) syndrome is rare and characterized by a low heart beat and severe-to-profound deafness. Additional features include fatigue, dizziness, and episodic syncope. The sinoatrial node (SAN) drives heart automaticity and continuously regulates heart rate.
Liaqat K +17 more
europepmc +6 more sources
RyR2(R4496C) Expression Induces Sinoatrial Node Dysfunction [PDF]
Biophysical Journal, 2011 Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an arrhythmogenic disease characterized by stress-triggered syncope and sudden death. While ventricular tachycardia appears only during stress conditions, CPVT patients manifest basal sino-atrial node (SAN) dysfunction, but the underlying mechanism remains unknown.
Patricia Ñeco +7 more
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Electrophysiologic effects of lidocaine on sinus node and atrium in patients with and without sinoatrial dysfunction. [PDF]
Circulation, 1978 Electrophysiological studies were conducted in 13 patients with normal sinus node function and 14 with sinus node dysfunction before and after intravenous lidocaine. Mean +/- SEM sinus cycle length significantly shortened from 810 +/- 34.3 to 774 +/- 34.3 msec in patients with normal sinus node (P less than 0.001) and from 1061 +/- 67.6 to 1016 +/- 64 ...
Ramesh C. Dhingra +6 more
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Familial sinoatrial node dysfunction. Increased vagal tone a possible aetiology. [PDF]
Heart, 1976 Clinical and electrophysiological studies of a 13-year-old boy with sinus bradycardia revealed sinus node dysfunction. Long-term follow-up data of members of his family indicated familial sinus node dysfucntion. Increased vagal tone was present in all patients.
Dennis G. Caralis, P.Jacob Varghese
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Aging and Sinoatrial Node Dysfunction [PDF]
Circulation, 2007 In the century since the discovery by Keith and Flack of the sinoatrial node in the mole heart, a detailed mosaic of its cellular, anatomic, and electrophysiological properties has emerged. The human sinus node has been found to be anatomically constant and well localized, occupying an approximately 10-mm subepicardial region on the sulcus terminalis ...
Haris M. Haqqani, Jonathan M. Kalman
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Sinus Node Dysfunction and Atrial Fibrillation Associated with Isolated Sinoatrial Node Artery Ectasia [PDF]
Electronic Journal of General Medicine, 2013 A 74 year-old female patient was admitted to emergency service with a complaints of dizziness and shortness of breath. Complete atrioventricular block was observed and patient was followed up two days with transient transvenous cardiac pacemaker. Afterthat, atrial fibrillation (AF) was progressed and then, coronary angiography was scheduled.
Ahmet Karabulut, Bülent Uzunlar
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Sinus node recovery time and calculated sinoatrial conduction time in normal subjects and patients with sinus node dysfunction. [PDF]
Circulation, 1977 In 61 patients sinus node function was tested by programmed (sinoatrial conduction time, SACT) and overdrive atrial pacing (sinus node recovery time, SRT). In the control group (N = 20), mean sinus cycle length was 773 +/- 140.2 msec, mean absolute SRT 1044 +/- 215.8 msec [corrected SRT (CSRT) 270 +/- 112.5 msec; mean +/- SD] and calculated SACT was 82
G. Breithardt, L Seipel, F Loogen
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Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation [PDF]
Heart Rhythm, 2009 The mechanism of sinoatrial node (SAN) dysfunction in atrial fibrillation (AF) is unclear.The purpose of this study was to test the hypothesis that defective spontaneous sarcoplasmic reticulum (SR) Ca(2+) release (Ca(2+) clock) is in part responsible for SAN dysfunction in AF.Arrhythmic events and SAN function were evaluated in pacing-induced AF dogs ...
Boyoung Joung +10 more
openalex +6 more sources
Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels [PDF]
Cell, 2000 Voltage-gated L-type Ca2+ channels (LTCCs) containing a pore-forming alpha1D subunit (D-LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to total L-type Ca2+ currents and their physiological role and significance as a drug target remain unknown.
Josef Platzer +7 more
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Staged operation to fontan increases the incidence of sinoatrial node dysfunction [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1996 Morbidity and mortality of total cavopulmonary connection (modified Fontan procedure) may be decreased in many patients with single ventricle in whom the risk of surgery is high by performing the operations in a staged fashion. Each operative intervention, however, exposes the sinoatrial node region to risk of injury, and a multistaged approach may ...
Peter B. Manning +4 more
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