Results 21 to 30 of about 10,498 (222)

Pharmacologic Approach to Sinoatrial Node Dysfunction. [PDF]

Annu Rev Pharmacol Toxicol, 2021
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Mesirca P, Fedorov VV, Hund TJ, Torrente AG, Bidaud I, Mohler PJ, Mangoni ME.   +6 more
europepmc   +6 more sources

Insulin mitigates acute ischemia–induced atrial fibrillation and sinoatrial node dysfunction ex vivo [PDF]

JCI Insight
Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood.
Huiliang Qiu, Fan Li, Hannah Prachyl, Alejandra Patino-Guerrero, Michael Rubart, Wuqiang Zhu   +5 more
doaj   +4 more sources

D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism. [PDF]

Aging (Albany NY), 2023
With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field.
Zhang H, Chen C, Liu Y, Chen W, Qi J, Xu Y, Ren L, Yang G, Min D, Liu Z, Cai X, Hao M, Xu G, Hou P.   +13 more
europepmc   +5 more sources

Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. [PDF]

J Gerontol A Biol Sci Med Sci, 2022
Abstract Heart rate (HR) is controlled by the sinoatrial node (SAN). SAN dysfunction is highly prevalent in aging; however, not all individuals age at the same rate. Rather, health status during aging is affected by frailty. Natriuretic peptides regulate SAN function in part by activating natriuretic peptide receptor C (NPR-C).
Jansen HJ, Moghtadaei M, Rafferty SA, Belke DD, Rose RA.   +4 more
europepmc   +5 more sources

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction. [PDF]

Circulation, 2022
Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Mesquita T, Zhang R, Cho JH, Zhang R, Lin YN, Sanchez L, Goldhaber JI, Yu JK, Liang JA, Liu W, Trayanova NA, Cingolani E.   +11 more
europepmc   +7 more sources

Medical Management of Hemodynamically Unstable Sinoatrial Node Dysfunction in a Patient With Intracardiac Lymphoma. [PDF]

JACC CardioOncol, 2021
[Figure: see text]
Martz CA, Jarbeau JF, Castillo JJ, Fisher DC, Nohria A.   +4 more
europepmc   +4 more sources

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. [PDF]

Cardiovasc Diabetol, 2014
The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, patients with diabetes have faster heart rates compared to non-diabetic individuals, yet diabetic patients are frequently found among patients ...
Soltysinska E, Speerschneider T, Winther SV, Thomsen MB.   +3 more
europepmc   +7 more sources

The role of the calcium and the voltage clocks in sinoatrial node dysfunction. [PDF]

Yonsei Med J, 2011
Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. However, the relative importance of the voltage clock and Ca(2+) clock for pacemaking was not revealed in sick ...
Joung B, Chen PS, Lin SF.
europepmc   +6 more sources

Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]

Frontiers in Cardiovascular Medicine
Pulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang, Enyuan Zhang, Le He, Henan Zhang, Jing Xu, Fengmin Lu, Dongyan Wu, Yitong Yin, Wei Ma   +8 more
doaj   +2 more sources

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models [PDF]

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +2 more sources