The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction [PDF]
Journal of Interventional Cardiac Electrophysiology, 2015 The sinoatrial node (SAN) and the atrioventricular node (AVN) are the anatomical and functional regions of the heart which play critical roles in the generation and conduction of the electrical impulse. Their functions are ensured by peculiar structural cytological properties and specific collections of ion channels.
Raffaella Milanesi +2 more
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Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities
Experimental and Therapeutic Medicine, 2017 Atrial fibrillation (AF) is associated with mitochondrial dysfunction. Sinoatrial node (SAN) dysfunction increases arrhythmogenesis of pulmonary veins (PVs), which is the most important trigger of AF; however, it is not clear whether mitochondrial dysfunction differentially regulates electrical activity of SANs and PVs.
Yung‐Kuo Lin +7 more
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Changes in Ion Channel Gene Expression Underlying Heart Failure-Induced Sinoatrial Node Dysfunction [PDF]
Circulation: Heart Failure, 2011 Background— Heart failure (HF) causes a decline in the function of the pacemaker of the heart—the sinoatrial node (SAN). The aim of the study was to investigate HF-induced changes in the expression of the ion channels and related proteins underlying the pacemaker activity of the SAN.
Joseph Yanni +7 more
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Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review [PDF]
Frontiers in Cardiovascular MedicineSick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial ...
Xinxin Shi +12 more
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Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction [PDF]
Frontiers in Cardiovascular MedicineIntroductionLithium is a well-known agent to cause systemic toxicity with its narrow therapeutic window. Toxic cardiac effects are known but seldomly reported and can manifest as sinus node dysfunction (SND) ranging from delayed conduction to sinus ...
J. Curran Henson +4 more
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Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life? [PDF]
Journal of Cardiovascular Development and DiseaseBackground: Sinus bradycardia and first-/second-degree atrioventricular (AV) block in athletes are traditionally considered secondary to increased vagal tone and therefore reversible.
Sergei Bondarev +5 more
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Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression [PDF]
Circulation, 2004 Background— Homozygous mutant mice with a defect of klotho gene expression ( kl/kl ) show multiple age-related disorders and premature death from unknown causes. Methods and Results—
Kyosuke Takeshita +17 more
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Mechanism of Sinoatrial Node Dysfunction in a RyR 2 R420Q Mouse Model Ofcatecholaminergic Polymorphic Ventricular Tachycardia [PDF]
Biophysical Journal, 2017 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disease characterized by stress-induced syncope and/or sudden death in young individuals with structurally normal heart. More than 150 mutations located in the cardiac Ca2+ release channel (type-2 ryanodine receptor, RyR2) gene are related to CPVT. Besides ventricular tachycardia
Yueyi Wang +11 more
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The electrophysiological effects of Tongyang Huoxue granules on the ignition phase during hypoxia/reoxygenation injury in sinoatrial node cells [PDF]
Frontiers in PhysiologyIntroductionThis study was undertaken to explore the potential therapeutic effects of Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac disorder characterized by impaired impulse generation or conduction.
Qiaomin Wu +6 more
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