The World Congress of Insulin Resistance, Diabetes and Cardiovascular Disease (WCIRDC)
, 2023 Journal of Diabetes, Volume 15, Issue 1, Page 4-6, January 2023.
Zachary T. Bloomgarden
wiley +1 more source
A Case of Complete AV Blockade in Patient with Lyme Borreliosis
Архивъ внутренней медицины, 2022 Lyme disease (tick-borne borreliosis) is an infectious vector-borne natural focal disease that tends to a chronic and recurrent course with a predominant damage to the skin, nervous system, musculoskeletal system and heart. Cardiac features is manifested,
O. N. Denisov +2 more
doaj +1 more source
Structural and Electrical Remodeling of the Sinoatrial Node in Diabetes: New Dimensions and Perspectives [PDF]
, 2022 The sinoatrial node (SAN) is composed of highly specialized cells that mandate the spontaneous beating of the heart through self-generation of an action potential (AP).
Al Kury, Lina T. +4 more
core +2 more sources
Tbx18 and the generation of a biological pacemaker. Are we there yet? [PDF]
, 2016 A group of approximately 10,000 cells in the sinoatrial node (SAN), which is located at the entry of the right superior caval vein into the right atrium, is responsible for regular heart beating under different physiological conditions [1]. While the SAN
Brand, T
core +1 more source
Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function [PDF]
, 2021 The sinoatrial node (SAN) is the primary pacemaker of the heart and is responsible for generating the intrinsic heartbeat. Within the SAN, spontaneously active pacemaker cells initiate the electrical activity that causes the contraction of all ...
Biel, Martin +5 more
core +1 more source
Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. [PDF]
PLoS ONE, 2013 In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and ...
Alondra Albarado-Ibañez +4 more
doaj +1 more source
Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
doaj +1 more source
Journal of Investigative Medicine High Impact Case Reports, 2022 Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest.
Ebubechukwu Ezeh MD +6 more
doaj +1 more source
Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development. [PDF]
, 2020 Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease.
Frasch, Martin G, Giussani, Dino A
core +4 more sources
Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]
Pis'ma v ZhETP (JETP Lett.), 93 (7), 446-452 (2011), 2011 We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.
arxiv +1 more source