Results 61 to 70 of about 10,498 (222)

Insulin signaling is critical for sinoatrial node maintenance and function

Experimental and Molecular Medicine, 2023
Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their physiological role in the cells of the cardiac conduction system has never been explored. Therefore, we sought to
Sangmi Ock, Seong Woo Choi, Seung Hee Choi, Hyun Kang, Sung Joon Kim, Wang-Soo Lee, Jaetaek Kim   +6 more
doaj   +1 more source

Effect of selective heart rate slowing in heart failure with preserved ejection fraction [PDF]

, 2015
Background Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy.
Ashrafian, Houman, Dawson, Dana K., Dwight, Jeremy S., Francis, Jane M., Frenneaux, Michael, Mahmod, Masliza, Neubauer, Stefan, Pal, Nikhil, Rudd, Amelia, Singh, Satnam, Sivaswamy, Nadiya, Watkins, Hugh, Yavari, Arash   +12 more
core   +2 more sources

Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation [PDF]

Heart Rhythm, 2009
The mechanism of sinoatrial node (SAN) dysfunction in atrial fibrillation (AF) is unclear.The purpose of this study was to test the hypothesis that defective spontaneous sarcoplasmic reticulum (SR) Ca(2+) release (Ca(2+) clock) is in part responsible for SAN dysfunction in AF.Arrhythmic events and SAN function were evaluated in pacing-induced AF dogs ...
Boyoung Joung, Shien-Fong Lin, Zhenhui Chen, Patrick Antoun, Mitsunori Maruyama, Seongwook Han, Gianfranco Piccirillo, Marcelle A. Stucky, Douglas P. Zipes, Peng‐Sheng Chen, Mithilesh K. Das   +10 more
openalex   +6 more sources

Holter monitoring in patients with transient and focal ischemic attacks of the brain [PDF]

, 1986
The results of Holter monitoring in 100 patients with transient and focal cerebral ischemia were studied retrospectively. Atrial fibrillation (AF) was found in five patients compared with two from a group of 100 age and sex-matched control patients. Four
Gijn, J. (Jan) van, Kappelle, L.J. (Jaap), Klootwijk, A.P.J. (Peter), Koudstaal, P.J. (Peter), Meché, F.G.A. (Frans) van der   +4 more
core   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Rare Case of Rapidly Worsening REM Sleep Induced Bradycardia

Case Reports in Cardiology, 2015
Sinoatrial arrest also known as sinus pause occurs when sinoatrial node of the heart transiently ceases to generate the electrical impulse necessary for the myocardium to contract. It may last from 2.0 seconds to several minutes. Etiologies of sinoatrial
Ayyappa S. Duba, Suneetha Jasty, Ankit Mahajan, Vijay Kodadhala, Raza Khan, Prithviraj Rai, Mohammad Ghazvini   +6 more
doaj   +1 more source

Heart Rate Reserve in Fontan Patients: Chronotropic Incompetence or Hemodynamic Limitation?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Patients with a Fontan circulation achieve lower peak heart rates (HR) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain.
Guido Claessen, Andre La Gerche, Alexander Van De Bruaene, Mathias Claeys, Rik Willems, Steven Dymarkowski, Jan Bogaert, Piet Claus, Werner Budts, Hein Heidbuchel, Marc Gewillig   +10 more
doaj   +1 more source

Cell-based Biological Pacemakers: Progress and Problems [PDF]

, 2018
The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases.
Ito, Hiroshi, Nakamura, Kazufumi, Saito, Yukihiro   +2 more
core   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Pulsed Field Ablation for Atrial Fibrillation in Patients With Obesity: Procedural and Clinical Outcomes

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Procedural and clinical outcomes in patients with obesity undergoing catheter ablation for atrial fibrillation (AF) have been mixed. Clinical data in the context of pulsed field ablation (PFA) are currently limited in this patient cohort.
Francis J. Ha, Duron Prinsloo, Edwin Xu, Hui Chen Han, Nitesh Nerlekar, Adam J. Brown, Emily Kotschet   +6 more
wiley   +1 more source