Results 71 to 80 of about 10,441 (208)

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node

Scientific Reports, 2021
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression.
Ning Li, Esthela Artiga, Anuradha Kalyanasundaram, Brian J. Hansen, Amy Webb, Maciej Pietrzak, Brandon Biesiadecki, Bryan Whitson, Nahush A. Mokadam, Paul M. L. Janssen, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Vadim V. Fedorov   +13 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Controlling parasympathetic regulation of heart rate: a gatekeeperrole for RGS proteins in the sinoatrial node

Frontiers in Physiology, 2012
Neurotransmitters released from sympathetic and parasympathetic nerve terminals in the SAN exert their effects via G-protein-coupled receptors. Integration of these different G-protein signals within pacemaker cells of the sinoatrial node (SAN) is ...
Alexandra eMighiu, Scott Patrick Heximer
doaj   +1 more source

An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records.

PLOS Digital Health, 2022
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine.
Sergiusz Wesołowski, Gordon Lemmon, Edgar J Hernandez, Alex Henrie, Thomas A Miller, Derek Weyhrauch, Michael D Puchalski, Bruce E Bray, Rashmee U Shah, Vikrant G Deshmukh, Rebecca Delaney, H Joseph Yostl, Karen Eilbeck, Martin Tristani-Firouzi, Mark Yandell   +14 more
doaj   +1 more source

Estudio del sistema de marcapasos auriculares en el corazón del perro [PDF]

, 1998
Inclou referències ...
Bethencourt, Armando, Ferreira, Ignacio, Gómez Jaume, Alfredo, Palou, Andreu, Pastelin, Gustavo   +4 more
core  

Ivabradine: a preliminary observation for a new terapeutic role in patients with multiple organ dysfunction syndrome [PDF]

, 2014
[No abstract ...
De Santis, V, Frati, G, Greco, E, Tritapepe, L   +3 more
core   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity

Frontiers in Cardiovascular Medicine, 2021
The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner, Chen Kang, Pietro Mesirca, Juan Hong, Matteo E. Mangoni, Alexey V. Glukhov, Rajan Sah   +6 more
doaj   +1 more source

The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation [PDF]

, 2013
Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K+ current (IKACh) in the control of SAN pacemaking and heart rate is not ...
Audoubert, Matthieu, Clapham, David E., Couette, Brigitte, DiFrancesco, Mattia L., Dubel, Stefan, Leoni, Anne-Laure, Mangoni, Matteo E., Marger, Laurine, Mesirca, Pietro, Muller, Jana Christina, Nargeot, Joël, Rizzetto, Riccardo, Torrente, Angelo G., Toyoda, Futoshi, Wickman, Kevin   +14 more
core   +3 more sources