Results 81 to 90 of about 72,352 (232)

Paradigm shift: new concepts for HCN4 function in cardiac pacemaking [PDF]

, 2022
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are the molecular correlate of the I-f current and are critically involved in controlling neuronal excitability and the autonomous rhythm of the heart.
Biel, Martin, Fenske, Stefanie, Hennis, Konstantin, Wahl-Schott, Christian   +3 more
core   +1 more source

The Involvement of TRPC3 channels in Sinoatrial Arrhythmias

Frontiers in Physiology, 2015
Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu, Bon Hyang Lee, Sofie eTrajanovska, Guoliang eHao, David G Allen, Ming eLei, Mark B Cannell   +6 more
doaj   +1 more source

Holter monitoring, sinoatrial conduction time, prognosis [PDF]

, 2013
Background: To evaluate the usefulness of the Holter method of sinoatrial conduction time (SACT) calculation in predicting the future occurrence of sinus node disease, and the emergence of indications for permanent pacing in patients with unexplained ...
Kramarz, Elżbieta, Makowski, Karol
core   +2 more sources

IVABRADINE IN PATIENTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION: NEW DATA FROM THE SHIFT MULTICENTER RANDOMIZED TRIAL

Российский кардиологический журнал, 2016
Resting heart rate is a strong predictor of mortality and cardiovascular outcome in patients with chronic heart failure. А specific inhibitor of the If current in the sinoatrial node ivabradine improves clinical outcome in patients with heart failure and
S. N. Tereshchenko, I. V. Zirov, N. V. Romanova   +2 more
doaj   +1 more source

Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review) [PDF]

, 2017
Sick sinus syndrome (SSS) encompasses a group of disorders whereby the heart is unable to perform its pacemaker function, due to genetic and acquired causes.
Chan, C, Chan, Y, Keung, W, Laxton, V, Li, K, Li, R, Liu, T, Tse, G, Wong, A   +8 more
core   +2 more sources

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases [PDF]

, 2020
Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Asano, Yoshihiro, Beerens, Manu, Burch, Micah L, Buys, Eva, Chiang, David Y, Cui, Shihe, Fujino, Noboru, Fujita, Takashi, Funada, Akira, Furusho, Hiroshi, Hayashi, Kenshi, Hodatsu, Akihiko, Inoue, Masaru, Kaku, Bunji, Kato, Takeshi, Kawashiri, Masa-aki, Kelly, Amy E, Kita, Yoshihito, Kiviniemi, Tuomas O, Kobayashi, Isao, Konno, Tetsuo, Kurata, Yasutaka, MacRae, Calum A, Nagata, Yoji, Nakanishi, Chiaki, Namura, Masanobu, Nomura, Akihiro, Oe, Kotaro, Okada, Hirofumi, Onoue, Kenji, Saito, Yoshihiko, Sakamoto, Yuichiro, Sakata, Kenji, Sips, Patrick, Tada, Hayato, Takamura, Masayuki, Takashima, Seiji, Takeda, Yuko, Tanaka, Yoshihiro, Teramoto, Ryota, Tsuchiya, Taketsugu, Tsuda, Toyonobu, Usuda, Keiich, Yamagishi, Masakazu, Zhao, Yanbin   +44 more
core   +1 more source

Short and midterm outcome of intraprocedural sinus node dysfunction requiring stimulation during ablation of persistent atrial fibrillation

Europace, 2023
Funding Acknowledgements Type of funding sources: None. Background Ablation within the superior, antero-lateral portions of the right atrium has been described as a risk for sinus node dysfunction (SND) because of direct damage to the sinus node.
L. Pu, S. Ulbrich, T. Gaspar, Y. Huo, U. Richter, A. Zedda, J. Mayer, M. Ebert, S. Richter   +8 more
semanticscholar   +1 more source

Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression [PDF]

Circulation, 2004
Background— Homozygous mutant mice with a defect of klotho gene expression ( kl/kl ) show multiple age-related disorders and premature death from unknown causes. Methods and Results—
Kyosuke Takeshita, Toshihiko Fujimori, Yoko Kurotaki, Haruo Honjo, Hiroshi Tsujikawa, Kenji Yasui, Jong‐Kook Lee, Kaichiro Kamiya, Kiyoyuki Kitaichi, Koji Yamamoto, Masafumi Ito, Takahisa Kondo, Shigeo Iino, Yasuya Inden, Makoto Hirai, Toyoaki Murohara, Itsuo Kodama, Yo‐ichi Nabeshima   +17 more
openalex   +4 more sources

Computer Algorithms for Automated Detection and Analysis of Local Ca2+ Releases in Spontaneously Beating Cardiac Pacemaker Cells [PDF]

, 2017
Local Ca Releases (LCRs) are crucial events involved in cardiac pacemaker cell function. However, specific algorithms for automatic LCR detection and analysis have not been developed in live, spontaneously beating pacemaker cells. Here we measured LCRs using a high-speed 2D-camera in spontaneously contracting sinoatrial (SA) node cells isolated from ...
arxiv   +1 more source

Enhancing network robustness for malicious attacks [PDF]

Physical Review E 85, 066130 (2012), 2012
In a recent work [Proc. Natl. Acad. Sci. USA 108, 3838 (2011)], the authors proposed a simple measure for network robustness under malicious attacks on nodes. With a greedy algorithm, they found the optimal structure with respect to this quantity is an onion structure in which high-degree nodes form a core surrounded by rings of nodes with decreasing ...
arxiv   +1 more source