Results 1 to 10 of about 17,957 (192)

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias [PDF]

Nature Communications
Physiologically relevant increases in transcription factor dosage and their role in development and disease remain largely unexplored. Genomic deletions upstream of the Paired-like homeodomain transcription factor gene (PITX2), identified in patients ...
Lieve E. van der Maarel, M. Ridwane Mungroo, Otto J. Mulleners, Mathilde R. Rivaud, Arie O. Verkerk, Karel van Duijvenboden, Freek H. T. Tiel Groenestege, Jeffrey D. Steimle, Lianne Fokkert, Corrie de Gier-de Vries, Mischa Klerk, Arie. R. Boender, James F. Martin, Bjarke Jensen, Gerard J. J. Boink, Harsha D. Devalla, Vincent M. Christoffels   +16 more
doaj   +4 more sources

Selection of patients with symptomatic vagal-induced sinus node dysfunction: Who will be the best candidate for cardioneuroablation? [PDF]

Frontiers in Physiology, 2023
Sinus node dysfunction is a multifaceted disorder with variable manifestations, the prevalence of which increases with age. In a specific group of patients, excessive vagal activity may be the sole cause for this condition.
Simin Cai, Lihui Zheng, Yan Yao
doaj   +2 more sources

Sinus Node Dysfunction, Atrial Arrhythmias, and the Sinus Node Microcirculation

Clinical Medicine Insights: Case Reports, 2022
A patient with sinus node dysfunction (SND) developed atrial arrhythmias that were abolished after avoidance of nonsteroidal anti-inflammatory medication and by the institution of a deliberate, modest increase in blood pressure, suggesting that there was
Susan K Fellner
doaj   +3 more sources

Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction [PDF]

Frontiers in Cardiovascular Medicine
IntroductionLithium is a well-known agent to cause systemic toxicity with its narrow therapeutic window. Toxic cardiac effects are known but seldomly reported and can manifest as sinus node dysfunction (SND) ranging from delayed conduction to sinus ...
J. Curran Henson, Lauren Morehead, Joshua Hagood, Niroshi Wijewardane, Hakan Paydak   +4 more
doaj   +2 more sources

Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A)

Stem Cell Research
The heterozygous mutation c.155G > T in GNB2 clinically leads to sinus bradycardia and sinus node dysfunction. Here, patient-specific skin fibroblasts of the mutation carrier were used for Sendai virus reprogramming into human induced-pluripotent stem ...
Anne Kayser, Sven Dittmann, Jassin Hamidi, Sandra D. Laufer, Ramona Krampe, Giulia Mearini, Arne Hansen, Eric Schulze-Bahr   +7 more
doaj   +2 more sources

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs [PDF]

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +2 more sources

Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis [PDF]

BMC Neurology, 2021
Background Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels.
Makoto Shibata, Reona Hoshino, Chisato Shimizu, Masayuki Sato, Natsumi Furuta, Yoshio Ikeda   +5 more
doaj   +2 more sources

A case report of sinus node–sparing hybrid ablation for refractory sinus tachycardia following cardioneuroablation for sinus node dysfunction [PDF]

BMC Cardiovascular Disorders
Background Cardioneuroablation (CNA) is increasingly used worldwide in the treatment of functional bradyarrhythmia mediated by excessive vagal tone. However, a potential early or long-term complication is the development of postprocedural inappropriate ...
Sebastian Stec, Piotr Suwalski, Mark la Meir, Carlo de Asmundis, Marta Kornaszewska, Mariusz Kowalewski   +5 more
doaj   +2 more sources

Cardioneuroablation for the Treatment of Hypervagotonic Sinus Node Dysfunction [PDF]

JACC: Case Reports
Hypervagotonic sinus node dysfunction (SND) is a form of SND with sinus bradycardia caused by enhanced vagal tone. Indirect proof of hypervagotonia as the mechanism can be inferred from resolution of bradycardia following atropine infusion.
Arshneel Kochar, MD, Tyler Taigen, MD, Jeffery Courson, DO, Kenneth Mayuga, MD, Shady Nakhla, MD, Oussama Wazni, MD, MBA, Pasquale Santangeli, MD, PhD   +6 more
doaj   +2 more sources

Pheochromocytoma and sinus node dysfunction [PDF]

Baylor University Medical Center Proceedings, 2019
Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that can lead to detrimental outcomes; if identified and treated, they are associated with a good prognosis. The clinical presentation can vary greatly but is classically associated with tachycardia, headaches, and hypertension.
Mary Lee, Dane Langsjeon, Srikala Devabhaktuni, Greg Olsovsky   +3 more
openaire   +4 more sources