Results 241 to 250 of about 497,452 (342)

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Optimization of a synthetic siRNA delivery for the treatment of rhabdomyosarcoma

Open Life Sciences, 2008
Lesko Ewa, Miekus Katarzyna, Grabowska Agnieszka, Gładys Aleksandra, Majka Marcin   +4 more
doaj   +1 more source

Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis. [PDF]

Sci Adv
Chen Z, Yang J, Zhang Q, Zeng W, Liu Y, Hu W, Chen L, Shen J, Miao Y, Xiao Z, Wu Z, Wang H, Shen H, Ding C, Chen Q, Zhao J, Yang Y.   +16 more
europepmc   +1 more source

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

Advanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu, Maria A. Toma, Jennifer Geara, Xiaowei Bian, Yongjian Chen, Lihua Luo, Qizhang Wang, Yunting Xiao, Manika Vij, Minna Piipponen, Zhuang Liu, Sho Oasa, Letian Zhang, Dörte Schlesinger, Ákos Végvári, Dongqing Li, Aoxue Wang, Vladana Vukojević, Simon J Elsässer, Pehr Sommar, Ning Xu Landén   +20 more
wiley   +1 more source

Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [PDF]

Signal Transduct Target Ther
She H, Zheng J, Zhao G, Du Y, Tan L, Chen ZS, Wu Y, Li Y, Liu Y, Sun Y, Hu Y, Zuo D, Mao Q, Liu L, Li T.   +14 more
europepmc   +1 more source

Articles selected by Faculty of 1000: chromosome pairing in Arabidopsis; hybrid inviability in birds and mammals; endogenous siRNAs in Arabidopsis; evolution of sex-biased genes in Drosophila; human patterns of genetic variation [PDF]

, 2004

openalex   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Correction: PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway. [PDF]

Cytotechnology
Zhu C, Wang C, Wang X, Dong S, Xu Q, Zheng J.   +5 more
europepmc   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation. [PDF]

J Transl Med
Zhang K, Zhang W, Zhang L, Hou X, Tian R, Hu Z, Yin L, Hu Z.   +7 more
europepmc   +1 more source