Results 331 to 340 of about 497,452 (342)
Some of the next articles are maybe not open access.
2004
RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Sven N. Reske, Changxian Shen
openaire +3 more sources
RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Sven N. Reske, Changxian Shen
openaire +3 more sources
2009
With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Ryan Mesaros +2 more
openaire +3 more sources
With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Ryan Mesaros +2 more
openaire +3 more sources
2008
The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.
Vira Bitko, Sailen Barik
openaire +3 more sources
The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.
Vira Bitko, Sailen Barik
openaire +3 more sources
Detection of siRNAs and miRNAs
2008Small RNAs such as small interfering RNAs (siRNAs) and microRNAs (miRNAs) play crucial roles in establishing general host defense mechanisms against viral infections in plants and the development of disease symptoms. Understanding these fundamental processes requires the sensitive and specific detection of small RNA species.
Kauppinen, S., Havelda, Z.
openaire +3 more sources
Annealing siRNAs to Produce siRNA Duplexes
Cold Spring Harbor Protocols, 2006openaire +3 more sources
Bioinformatics of siRNA Design
2013RNA interference mediated by small interfering RNAs is a powerful tool for investigation of gene functions and is increasingly used as a therapeutic agent. However, not all siRNAs are equally potent, and although simple rules for the selection of good siRNAs were proposed early on, siRNAs are still plagued with widely fluctuating efficiency.
openaire +3 more sources
Topical antiviral siRNA: A practical siRNA microbicide? [PDF]
Gene Therapy, 2006 openaire +1 more source