Results 81 to 90 of about 382,657 (316)
Early Blockade of EphA4 Pathway Reduces Trigeminal Neuropathic Pain
Journal of Pain Research, 2020 Min-Ji Kim,* Jo-Young Son,* Jin-Sook Ju, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk AhnDepartment of Oral Physiology,
Kim MJ, Son JY, Ju JS, Ahn DK
doaj
, 2018 A. A representative immunocytochemistry results showing CUL5 distribution in control and thalidomide (50 μg/ml) treated HUVEC that were sham transfected or transfected with anti-VACM-1 specific siRNA. Magnification is 100X. B.
Zachary J. DeBruine (5204348) +11 more
core +1 more source
, 2021 Multiple drug-resistance mechanisms originate from defensive pathways in cancer and are associated with the unsatisfied efficacy of chemotherapy. The combination of small interfering RNA (siRNA) and chemotherapeutics provides a strategy for reducing drug
Lisen Lin +21 more
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
STUDY OF MODIFIED RECOMBINANT APOLIPOPROTEIN A-I AS A CARRIER OF SMALL INTERFERRING RNA
Сибирский научный медицинский журнал, 2019 With the widespread development of the phenomenon of RNA interference, currently, researchers are puzzled to obtain effective carriers of small interfering RNA (siRNA).
A. V. Ryabchenko +4 more
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siRNA-mediated knockdown of GluN3A mRNA in 46C-derived NSCs.
, 2018 46C-derived NSCs were either transfected with scrambled siRNA or siRNA directed against GluN3A. A: qRT-PCRs were performed to analyse the knockdown of GluN3A at the mRNA level.
Svenja Pachernegg (4849609) +6 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease [PDF]
Clinical and Molecular HepatologyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity and mortality.
Andrea Caddeo, Stefano Romeo
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A comparative study of cationic formulations for the delivery of siRNA and DNA
, 2009 RNA interference (RNAi) provides a specific and efficient way to silence gene expression; therefore, it is an attractive tool to be used in basic research on gene function as well as gene therapy.
Kwok, N.P.A.
core
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source